{
  "$schema": "https://foodadditiveindex.com/api/v1/schema.json",
  "id": "https://foodadditiveindex.com/additives/biotin",
  "slug": "biotin",
  "name": "Biotin",
  "identifiers": {
    "e_number": null,
    "ins_number": null,
    "cas_number": "58-85-5",
    "inchikey": "YBJHBAHKTGYVGT-ZKWXMUAHSA-N",
    "pubchem_cid": 171548
  },
  "functional_class": null,
  "summary": "Biotin is vitamin B7, added to infant formula, drinks and fortified foods.",
  "derivation_summary": "Produced by chemical synthesis, and increasingly by fermentation.",
  "regulatory_status": [
    {
      "jurisdiction": "US",
      "jurisdiction_name": "United States",
      "authority": "Food and Drug Administration",
      "status": "permitted",
      "status_label": "Permitted",
      "provision_count": 1,
      "provisions": [
        {
          "status": "permitted",
          "food_category": null,
          "max_level": null,
          "max_level_unit": null,
          "conditions": null,
          "effective_from": null,
          "citation": {
            "ref": "21 CFR 182.8159",
            "url": "https://www.ecfr.gov/current/title-21/section-182.8159"
          },
          "source": "ecfr",
          "retrieved_at": "2026-09-07T18:25:51.549Z"
        }
      ]
    },
    {
      "jurisdiction": "CODEX",
      "jurisdiction_name": "Codex Alimentarius",
      "authority": "Codex Alimentarius Commission / JECFA",
      "status": "not_listed",
      "status_label": "Not listed",
      "note": "Does not appear on this jurisdiction’s permitted list. That is not the same as being prohibited.",
      "provision_count": 0,
      "provisions": []
    }
  ],
  "names": [
    {
      "name": "58-85-5",
      "type": "cas",
      "source": "openfoodtox"
    },
    {
      "name": "(+)-Biotin",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "(+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno(3,4-d)imidazole-4-valeric acid",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1H-thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS,4S,6aR)-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "2'-Keto-3,4-imidazolido-2-tetrahydrothiophene-N-valeric acid",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanoic acid",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Amerix Biotin",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Beard",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Bioepiderm",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Bios II",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "BIOT",
      "type": "common",
      "source": "openfoodtox"
    },
    {
      "name": "biotin",
      "type": "common",
      "source": "openfoodtox"
    },
    {
      "name": "Biotin 100",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Biotin Drops",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Biotin Hair",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Biotin ratiopharm",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Biotina",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Biotine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Biotinum",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Biotitum",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Biotn",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Biotn Topical Serum",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Bonogen Activator",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Casotr Oil",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "cis-Hexahydro-2-oxo-1H-thieno(3,4)imidazole-4-valeric acid",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "cis-Tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "coenzyme R",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "D(+)-Biotin",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "D-(+)-Biotin",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "d-biotin",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "DRUGGIST Bar",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Factor S",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Factor S (vitamin)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Gelfert, Biotin",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Hair",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Hair Cream",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Hair Strengthens",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Hairq-plus",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Hermes, Biotin",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Hexahydro-2-oxo-1H-thieno(3,4-d)imidazole-4-pentanoic acid",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Hiar Growth",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Injacom H",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Ritatin",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Roche, Biotine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Roemary mint",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Spai-sons Procapell",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Spai-sons Prolac-vit",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "SUBIR",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "SUBIR EYELASH",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Tk-nax",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "TWINKLE ESSENCE",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Vitamin B-7",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Vitamin B7",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Vitamin Bw",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Vitamin Essentaial",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "vitamin H",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS-(3aalpha,4beta,6aalpha))-",
      "type": "iupac",
      "source": "pubchem"
    },
    {
      "name": "5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid",
      "type": "iupac",
      "source": "openfoodtox"
    },
    {
      "name": "Biotin",
      "type": "label",
      "source": "ecfr"
    }
  ],
  "hazard_reference_values": [],
  "sources": [
    {
      "key": "ecfr",
      "name": "Electronic Code of Federal Regulations, Title 21",
      "publisher": "U.S. Government Publishing Office / National Archives",
      "licence": "Public domain",
      "url": "https://www.ecfr.gov/api/versioner/v1/full/2026-08-31/title-21.xml",
      "retrieved_at": "2026-09-07T18:25:51.549Z"
    }
  ],
  "citation_policy": "Cite as: Food Additive Index, \"Biotin\", https://foodadditiveindex.com/additives/biotin. This site reports regulatory status and does not rate additives.",
  "generated_at": "2026-09-08T00:09:38.435Z"
}