{
  "$schema": "https://foodadditiveindex.com/api/v1/schema.json",
  "id": "https://foodadditiveindex.com/additives/caffeine",
  "slug": "caffeine",
  "name": "Caffeine",
  "identifiers": {
    "e_number": null,
    "ins_number": null,
    "cas_number": "58-08-2",
    "inchikey": "RYYVLZVUVIJVGH-UHFFFAOYSA-N",
    "pubchem_cid": 2519
  },
  "functional_class": null,
  "summary": "Caffeine is added to cola and energy drinks as a bittering agent and stimulant. In the United States its use in cola is a specific GRAS listing rather than a general permission.",
  "derivation_summary": "Extracted from coffee and tea — decaffeination produces it as a by-product, so the caffeine in a cola may have come out of somebody's decaf — or produced by chemical synthesis.",
  "regulatory_status": [
    {
      "jurisdiction": "US",
      "jurisdiction_name": "United States",
      "authority": "Food and Drug Administration",
      "status": "permitted",
      "status_label": "Permitted",
      "provision_count": 1,
      "provisions": [
        {
          "status": "permitted",
          "food_category": null,
          "max_level": null,
          "max_level_unit": null,
          "conditions": null,
          "effective_from": null,
          "citation": {
            "ref": "21 CFR 182.1180",
            "url": "https://www.ecfr.gov/current/title-21/section-182.1180"
          },
          "source": "ecfr",
          "retrieved_at": "2026-09-07T18:25:51.549Z"
        }
      ]
    },
    {
      "jurisdiction": "CODEX",
      "jurisdiction_name": "Codex Alimentarius",
      "authority": "Codex Alimentarius Commission / JECFA",
      "status": "not_listed",
      "status_label": "Not listed",
      "note": "Does not appear on this jurisdiction’s permitted list. That is not the same as being prohibited.",
      "provision_count": 0,
      "provisions": []
    }
  ],
  "names": [
    {
      "name": "58-08-2",
      "type": "cas",
      "source": "openfoodtox"
    },
    {
      "name": "1,3,7-trimethyl-1H-purine-2,6(3H,7H)-dione",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1,3,7-Trimethyl-2,6-dioxopurine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1,3,7-Trimethyl-3,7-dihydro-1H-purine-2,6-dione",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1,3,7-Trimethylpurine-2,6-dione",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1,3,7-Trimethylxanthine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1-methyltheobromine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5-26-13-00558 (Beilstein Handbook Reference)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "7-Methyltheophylline",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Alert-pep",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Anhydrous caffeine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Cafamil",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Cafecon",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Cafeina",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "cafeine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Caffedrine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Caffein",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Caffeina",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "caffeine",
      "type": "common",
      "source": "openfoodtox"
    },
    {
      "name": "Caffeine melting point standard",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Caffeine, anhydrous",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Caffeinum",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Caffine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "CAFFN",
      "type": "common",
      "source": "openfoodtox"
    },
    {
      "name": "Cafipel",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Coffein",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Coffeine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Coffeinum",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Dexitac",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Durvitan",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Eldiatric C",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "FEMA No. 2224",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Guaranine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Hycomine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Kofein",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Koffein",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Mateina",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Methyltheobromide",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Methyltheobromine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Methylxanthine theophylline",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Nix Nap",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "No-Doz",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Nodaca",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "NODOZ",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "NoDoz Caplets and Chewable Tablets",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Organex",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Quick Pep",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "QuickPep",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Refresh'n",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Stim",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "teina",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Thein",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Theine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Tirend",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "TREZIX COMPONENT CAFFEINE",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Tri-Aqua",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Vivarin",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione",
      "type": "iupac",
      "source": "openfoodtox"
    },
    {
      "name": "Caffeine",
      "type": "label",
      "source": "ecfr"
    }
  ],
  "hazard_reference_values": [],
  "sources": [
    {
      "key": "ecfr",
      "name": "Electronic Code of Federal Regulations, Title 21",
      "publisher": "U.S. Government Publishing Office / National Archives",
      "licence": "Public domain",
      "url": "https://www.ecfr.gov/api/versioner/v1/full/2026-08-31/title-21.xml",
      "retrieved_at": "2026-09-07T18:25:51.549Z"
    }
  ],
  "citation_policy": "Cite as: Food Additive Index, \"Caffeine\", https://foodadditiveindex.com/additives/caffeine. This site reports regulatory status and does not rate additives.",
  "generated_at": "2026-09-08T00:09:38.441Z"
}