{
  "$schema": "https://foodadditiveindex.com/api/v1/schema.json",
  "id": "https://foodadditiveindex.com/additives/calcium-disodium-edta",
  "slug": "calcium-disodium-edta",
  "name": "Calcium disodium EDTA",
  "identifiers": {
    "e_number": "E385",
    "ins_number": "385",
    "cas_number": "62-33-9",
    "inchikey": "SHWNNYZBHZIQQV-UHFFFAOYSA-J",
    "pubchem_cid": 6093170
  },
  "functional_class": "Preservative",
  "summary": "Calcium disodium EDTA is a sequestrant that binds trace metals, preventing the discolouration, rancidity and flavour loss they cause. It is used in dressings, canned goods, sauces and soft drinks.",
  "derivation_summary": "Synthesised from ethylenediamine and chloroacetic acid, then complexed with calcium and sodium. The calcium form is used in food rather than the disodium form because it does not strip calcium from the body.",
  "regulatory_status": [
    {
      "jurisdiction": "US",
      "jurisdiction_name": "United States",
      "authority": "Food and Drug Administration",
      "status": "permitted_with_conditions",
      "status_label": "Permitted, with conditions",
      "provision_count": 1,
      "provisions": [
        {
          "status": "permitted_with_conditions",
          "food_category": null,
          "max_level": null,
          "max_level_unit": null,
          "conditions": null,
          "effective_from": null,
          "citation": {
            "ref": "21 CFR 172.120",
            "url": "https://www.ecfr.gov/current/title-21/section-172.120"
          },
          "source": "ecfr",
          "retrieved_at": "2026-09-07T18:25:51.549Z"
        }
      ]
    },
    {
      "jurisdiction": "CODEX",
      "jurisdiction_name": "Codex Alimentarius",
      "authority": "Codex Alimentarius Commission / JECFA",
      "status": "permitted_with_conditions",
      "status_label": "Permitted, with conditions",
      "provision_count": 36,
      "provisions": [
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "02.2.2",
            "name": "Fat spreads, dairy fat spreads and blended spreads"
          },
          "max_level": 100,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21 & XS253",
          "effective_from": "2023",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 02.2.2",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.1.2.10",
            "name": "Fermented fruit products"
          },
          "max_level": 250,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21",
          "effective_from": "2008",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 04.1.2.10",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.1.2.11",
            "name": "Fruit fillings for pastries"
          },
          "max_level": 650,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21",
          "effective_from": "2001",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 04.1.2.11",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.1.2.2",
            "name": "Dried fruit"
          },
          "max_level": 265,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21",
          "effective_from": "2001",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 04.1.2.2",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.1.2.3",
            "name": "Fruit in vinegar, oil, or brine"
          },
          "max_level": 250,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21",
          "effective_from": "2008",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 04.1.2.3",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.1.2.5",
            "name": ""
          },
          "max_level": 130,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21",
          "effective_from": "2001",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 04.1.2.5",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.1.2.6",
            "name": "Fruit-based spreads (e.g. chutney) excluding products of food category"
          },
          "max_level": 100,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21 & XS160",
          "effective_from": "2023",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 04.1.2.6",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.2.2.1",
            "name": "Frozen vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweeds and nuts and seeds"
          },
          "max_level": 100,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21 & 93",
          "effective_from": "2024",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 04.2.2.1",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.2.2.2",
            "name": "Dried vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweeds, and nuts and seeds"
          },
          "max_level": 800,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21, 64, 297, 613 & XS336R",
          "effective_from": "2026",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 04.2.2.2",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.2.2.3",
            "name": "Vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), and seaweeds in vinegar, oil, brine, or soybean sauce"
          },
          "max_level": 250,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21 & 216",
          "effective_from": "2024",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 04.2.2.3",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.2.2.4",
            "name": "Canned or bottled (pasteurized) or retort pouch vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), and seaweeds"
          },
          "max_level": 365,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21, XS57, XS257R & 651",
          "effective_from": "2025",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 04.2.2.4",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.2.2.5",
            "name": "Vegetable (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweed, and nut and seed purees and spreads (e.g. peanut butter)"
          },
          "max_level": 250,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21 & XS57",
          "effective_from": "2024",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 04.2.2.5",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.2.2.6",
            "name": "Vegetable (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweed, and nut and seed pulps and preparations (e.g. vegetable desserts and sauces, candied vegetables) other than food category 04.2.2.5"
          },
          "max_level": 80,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21, XS57, XS259R & XS308R",
          "effective_from": "2025",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 04.2.2.6",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.2.2.7",
            "name": "Fermented vegetable (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera) and seaweed products, excluding fermented soybean products of food categories 06.8.6, 06.8.7, 12.9.1,"
          },
          "max_level": 250,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21 & XS294",
          "effective_from": "2023",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 04.2.2.7",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.2.2.8",
            "name": "Cooked or fried vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), and seaweeds"
          },
          "max_level": 250,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21, 613 & XS334R",
          "effective_from": "2026",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 04.2.2.8",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "05.1.3",
            "name": "Cocoa-based spreads, incl. fillings"
          },
          "max_level": 50,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21 & XS86",
          "effective_from": "2016",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 05.1.3",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "06.5",
            "name": "Cereal and starch based desserts (e.g. rice pudding, tapioca pudding)"
          },
          "max_level": 315,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21",
          "effective_from": "2001",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 06.5",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "08.3.2",
            "name": "Heat-treated processed comminuted meat, poultry, and game products"
          },
          "max_level": 35,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21, XS88, XS89 & XS98",
          "effective_from": "2014",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 08.3.2",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "09.2.1",
            "name": "Frozen fish, fish fillets, and fish products, including molluscs, crustaceans, and echinoderms"
          },
          "max_level": 75,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21, 392, XS36, XS92, XS95, XS165, XS190, XS191, XS312 & XS315",
          "effective_from": "2017",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 09.2.1",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "09.2.2",
            "name": "Frozen battered fish, fish fillets and fish products, including molluscs, crustaceans, and echinoderms"
          },
          "max_level": 75,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21 & XS166",
          "effective_from": "2017",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 09.2.2",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "09.2.4.1",
            "name": "Cooked fish and fish products"
          },
          "max_level": 50,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21",
          "effective_from": "2005",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 09.2.4.1",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "09.3.2",
            "name": "Fish and fish products, including molluscs, crustaceans and echinoderms, pickled and/or in brine"
          },
          "max_level": 250,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21",
          "effective_from": "2001",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 09.3.2",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "09.4",
            "name": "Fully preserved, including canned or fermented fish and fish products, including molluscs, crustaceans, and echinoderms"
          },
          "max_level": 340,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21, 310, XS3, XS70, XS94 & XS119",
          "effective_from": "2018",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 09.4",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "10.2.3",
            "name": "Dried and/or heat coagulated egg products"
          },
          "max_level": 200,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21 & 47",
          "effective_from": "2001",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 10.2.3",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "11.6",
            "name": "Table-top sweeteners, including those containing high-intensity sweeteners"
          },
          "max_level": 1000,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21 & 96",
          "effective_from": "2005",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 11.6",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "12.2",
            "name": "Herbs, spices, seasonings, and condiments (e.g. seasoning for instant noodles)"
          },
          "max_level": 70,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21, XS326, XS327, XS328, XS342, XS343, XS344, XS345, XS347, XS351, XS352 & XS353",
          "effective_from": "2025",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 12.2",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "12.4",
            "name": "Mustards"
          },
          "max_level": 75,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21",
          "effective_from": "2001",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 12.4",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "12.6.1",
            "name": "Emulsified sauces and dips (e.g. mayonnaise, salad dressing, onion dips)"
          },
          "max_level": 100,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21",
          "effective_from": "2001",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 12.6.1",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "12.6.2",
            "name": "Non-emulsified sauces (e.g. ketchup, cheese sauce, cream sauce, brown gravy)"
          },
          "max_level": 75,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 21 & 575",
          "effective_from": "2023",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 385, food category 12.6.2",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
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}