{
  "$schema": "https://foodadditiveindex.com/api/v1/schema.json",
  "id": "https://foodadditiveindex.com/additives/calcium-gluconate",
  "slug": "calcium-gluconate",
  "name": "Calcium gluconate",
  "identifiers": {
    "e_number": null,
    "ins_number": "578",
    "cas_number": "299-28-5",
    "inchikey": "NEEHYRZPVYRGPP-IYEMJOQQSA-L",
    "pubchem_cid": 9290
  },
  "functional_class": "Acidity regulator",
  "summary": "Calcium gluconate is a firming agent and calcium fortificant, used in canned fruit and vegetables and in supplements.",
  "derivation_summary": "Made by fermenting glucose to gluconic acid and neutralising it with a calcium base.",
  "regulatory_status": [
    {
      "jurisdiction": "US",
      "jurisdiction_name": "United States",
      "authority": "Food and Drug Administration",
      "status": "permitted",
      "status_label": "Permitted",
      "provision_count": 1,
      "provisions": [
        {
          "status": "permitted",
          "food_category": null,
          "max_level": null,
          "max_level_unit": null,
          "conditions": null,
          "effective_from": null,
          "citation": {
            "ref": "21 CFR 184.1199",
            "url": "https://www.ecfr.gov/current/title-21/section-184.1199"
          },
          "source": "ecfr",
          "retrieved_at": "2026-09-07T18:25:51.549Z"
        }
      ]
    },
    {
      "jurisdiction": "CODEX",
      "jurisdiction_name": "Codex Alimentarius",
      "authority": "Codex Alimentarius Commission / JECFA",
      "status": "permitted_with_conditions",
      "status_label": "Permitted, with conditions",
      "provision_count": 2,
      "provisions": [
        {
          "status": "permitted",
          "food_category": null,
          "max_level": null,
          "max_level_unit": "GMP",
          "conditions": null,
          "effective_from": "1999",
          "citation": {
            "ref": "CXS 192-1995 Table Three, INS 578",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "01.2.1.2",
            "name": "Fermented milks (plain), heat-treated after fermentation"
          },
          "max_level": null,
          "max_level_unit": "GMP",
          "conditions": "GSFA notes: 630",
          "effective_from": "2024",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 578, food category 01.2.1.2",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        }
      ]
    }
  ],
  "names": [
    {
      "name": "299-28-5",
      "type": "cas",
      "source": "ecfr"
    },
    {
      "name": "2,3,4,5,6-Pentahydroxycaproic Acid hemicalcium salt",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "23% Calcium Gluconate",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "C12H22CaO14",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcarea gluconica",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcicol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcii gluconas",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calciofon",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcipur",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "calcium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcium D-gluconate",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcium D-gluconate (1:2)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcium D-gluconate;Gluconic acid hemicalcium salt",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "calcium di(D-gluconate)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcium di-gluconate",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "CALCIUM GLUCONATE",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcium gluconate (USP)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcium Gluconate 1.5%",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcium Gluconate 23% Solution",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcium gluconate anhydrous",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcium gluconate hydrate",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "CALCIUM GLUCONATE IN SODIUM CHLORIDE",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcium hexagluconate",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calglucol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calglucon",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "CCRIS 1336",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "D-Gluconic acid calcium salt",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "D-GLUCONIC ACID HEMICALCIUM SALT",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "D-Gluconic acid, calcium salt (2:1)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Dragocal",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Ebucin",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Glucal",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Glucobiogen",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Gluconate de calcium",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Gluconate, Calcium",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Gluconato di calcio",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Gluconic Acid Calcium Salt",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Gluconic acid hemicalcium salt",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Gluconic acid, calcium salt (2:1), D-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "GZE CUTICLE REMOVER",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "H-f antidote",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "HSDB 994",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "INS NO.578",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "INS-578",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Kalpren",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Novocal",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "SQE6VB453K",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Sykes Calcium Gluconate 23%",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "578",
      "type": "ins",
      "source": "gsfa"
    },
    {
      "name": "Calcium gluconate",
      "type": "label",
      "source": "ecfr"
    }
  ],
  "hazard_reference_values": [],
  "sources": [
    {
      "key": "ecfr",
      "name": "Electronic Code of Federal Regulations, Title 21",
      "publisher": "U.S. Government Publishing Office / National Archives",
      "licence": "Public domain",
      "url": "https://www.ecfr.gov/api/versioner/v1/full/2026-08-31/title-21.xml",
      "retrieved_at": "2026-09-07T18:25:51.549Z"
    },
    {
      "key": "gsfa",
      "name": "Codex General Standard for Food Additives (CXS 192-1995)",
      "publisher": "Codex Alimentarius Commission (FAO/WHO)",
      "licence": "FAO terms — non-commercial use with attribution",
      "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/",
      "retrieved_at": "2026-09-07T07:54:15.059Z"
    }
  ],
  "citation_policy": "Cite as: Food Additive Index, \"Calcium gluconate\", https://foodadditiveindex.com/additives/calcium-gluconate. This site reports regulatory status and does not rate additives.",
  "generated_at": "2026-09-08T00:09:38.448Z"
}