{
  "$schema": "https://foodadditiveindex.com/api/v1/schema.json",
  "id": "https://foodadditiveindex.com/additives/calcium-pyrophosphate",
  "slug": "calcium-pyrophosphate",
  "name": "Calcium pyrophosphate",
  "identifiers": {
    "e_number": "E450",
    "ins_number": "450(vi)",
    "cas_number": "7790-76-3",
    "inchikey": "JUNWLZAGQLJVLR-UHFFFAOYSA-J",
    "pubchem_cid": 24632
  },
  "functional_class": "Acidity regulator",
  "summary": "Calcium pyrophosphate is a buffer and nutrient, used in dental and food applications as a mild abrasive and calcium source.",
  "derivation_summary": "Produced by heating calcium phosphate to drive off water and condense the phosphate.",
  "regulatory_status": [
    {
      "jurisdiction": "US",
      "jurisdiction_name": "United States",
      "authority": "Food and Drug Administration",
      "status": "permitted",
      "status_label": "Permitted",
      "provision_count": 1,
      "provisions": [
        {
          "status": "permitted",
          "food_category": null,
          "max_level": null,
          "max_level_unit": null,
          "conditions": null,
          "effective_from": null,
          "citation": {
            "ref": "21 CFR 182.8223",
            "url": "https://www.ecfr.gov/current/title-21/section-182.8223"
          },
          "source": "ecfr",
          "retrieved_at": "2026-09-07T18:25:51.549Z"
        }
      ]
    },
    {
      "jurisdiction": "CODEX",
      "jurisdiction_name": "Codex Alimentarius",
      "authority": "Codex Alimentarius Commission / JECFA",
      "status": "permitted_with_conditions",
      "status_label": "Permitted, with conditions",
      "provision_count": 108,
      "provisions": [
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "01.1.1",
            "name": "Fluid Milk (plain)"
          },
          "max_level": 1500,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33 & 227",
          "effective_from": "2012",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 01.1.1",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "01.1.2",
            "name": "Other Fluid Milk (plain)"
          },
          "max_level": 2200,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33, 364, 411",
          "effective_from": "2018",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 01.1.2",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "01.1.3",
            "name": "Fluid Buttermilk (plain)"
          },
          "max_level": 1500,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33, 227 & 397",
          "effective_from": "2017",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 01.1.3",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "01.1.4",
            "name": "Flavoured Fluid Milk Drinks"
          },
          "max_level": 1500,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33, 364 & 610",
          "effective_from": "2024",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 01.1.4",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "01.2",
            "name": "Fermented and renneted milk products (plain),"
          },
          "max_level": 1000,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33, 610 & 635",
          "effective_from": "2024",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 01.2",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "01.3.1",
            "name": "Condensed milk (plain)"
          },
          "max_level": 880,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33, 565",
          "effective_from": "2023",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 01.3.1",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "01.3.2",
            "name": "Beverage whiteners"
          },
          "max_level": 13000,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33 & 480",
          "effective_from": "2021",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 01.3.2",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "01.4",
            "name": "Cream (plain) and the like"
          },
          "max_level": 2200,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33 & 617",
          "effective_from": "2024",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 01.4",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "01.5.1",
            "name": "Milk powder and cream powder (plain)"
          },
          "max_level": 4400,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33, 543, 548, 544 & 547",
          "effective_from": "2023",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 01.5.1",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "01.5.2",
            "name": "Milk and cream powder analogues"
          },
          "max_level": 4400,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33, 88, 482 & 483",
          "effective_from": "2021",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 01.5.2",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "01.6.1",
            "name": "Unripened cheese"
          },
          "max_level": 4400,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33, 487, 495, 496, 562, 564",
          "effective_from": "2023",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 01.6.1",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "01.6.4",
            "name": "Processed cheese"
          },
          "max_level": 9000,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33",
          "effective_from": "2012",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 01.6.4",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "01.6.5",
            "name": "Cheese analogues"
          },
          "max_level": 9000,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33",
          "effective_from": "2012",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 01.6.5",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "01.7",
            "name": "Dairy-based desserts (e.g. pudding, fruit or flavoured yoghurt)"
          },
          "max_level": 1500,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33 & 610",
          "effective_from": "2024",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 01.7",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "01.8.1",
            "name": "Liquid whey and whey products, excluding whey cheeses"
          },
          "max_level": 880,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33 & 228",
          "effective_from": "2012",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 01.8.1",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "01.8.2",
            "name": "Dried whey and whey products, excluding whey cheeses"
          },
          "max_level": 4400,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33 & XS331",
          "effective_from": "2023",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 01.8.2",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "02.2.1",
            "name": "Butter"
          },
          "max_level": 880,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33 & 34",
          "effective_from": "2008",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 02.2.1",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "02.2.2",
            "name": "Fat spreads, dairy fat spreads and blended spreads"
          },
          "max_level": 2200,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33, 530, 554, 555",
          "effective_from": "2023",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 02.2.2",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "02.3",
            "name": "Fat emulsions mainly of type oil-in-water, including mixed and/or flavoured products based on fat emulsions"
          },
          "max_level": 2200,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33",
          "effective_from": "2009",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 02.3",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "02.4",
            "name": "Fat-based desserts excluding dairy-based dessert products of food category 01.7"
          },
          "max_level": 1500,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33",
          "effective_from": "2012",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 02.4",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "03.0",
            "name": "Edible ices, including sherbet and sorbet"
          },
          "max_level": 7500,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33",
          "effective_from": "2012",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 03.0",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.1.2.10",
            "name": "Fermented fruit products"
          },
          "max_level": 2200,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33 & 636",
          "effective_from": "2024",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 04.1.2.10",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.1.2.11",
            "name": "Fruit fillings for pastries"
          },
          "max_level": 1500,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33",
          "effective_from": "2012",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 04.1.2.11",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.1.2.3",
            "name": "Fruit in vinegar, oil, or brine"
          },
          "max_level": 2200,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33 & 636",
          "effective_from": "2024",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 04.1.2.3",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.1.2.6",
            "name": "Fruit-based spreads (e.g. chutney) excluding products of food category"
          },
          "max_level": 1100,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33 & XS160",
          "effective_from": "2023",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 04.1.2.6",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.1.2.7",
            "name": "Candied fruit"
          },
          "max_level": 10,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33",
          "effective_from": "2012",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 04.1.2.7",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.1.2.8",
            "name": "Fruit preparations, including pulp, purees, fruit toppings and coconut milk"
          },
          "max_level": 350,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33 & XS314R",
          "effective_from": "2024",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 04.1.2.8",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.1.2.9",
            "name": "Fruit-based desserts, incl. fruit-flavoured water-based desserts"
          },
          "max_level": 1500,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33",
          "effective_from": "2012",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 04.1.2.9",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.2.1.2",
            "name": "Surface-treated fresh vegetables, (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweeds and nuts and seeds"
          },
          "max_level": 1760,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 16 & 33",
          "effective_from": "2009",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 04.2.1.2",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.2.1.3",
            "name": "Peeled, cut or shredded fresh vegetables, (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweeds and nuts and seeds"
          },
          "max_level": 5600,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33 & 76",
          "effective_from": "2012",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 450(vi), food category 04.2.1.3",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.2.2.1",
            "name": "Frozen vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweeds and nuts and seeds"
          },
          "max_level": 5000,
          "max_level_unit": "mg/kg",
          "conditions": "GSFA notes: 33, 76 & 637",
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