{
  "$schema": "https://foodadditiveindex.com/api/v1/schema.json",
  "id": "https://foodadditiveindex.com/additives/calcium-sulfate",
  "slug": "calcium-sulfate",
  "name": "Calcium sulfate",
  "identifiers": {
    "e_number": "E516",
    "ins_number": "516",
    "cas_number": "7778-18-9",
    "inchikey": "OSGAYBCDTDRGGQ-UHFFFAOYSA-L",
    "pubchem_cid": 24497
  },
  "functional_class": "Colour",
  "summary": "Calcium sulfate, or gypsum, is a firming agent and the other common tofu coagulant, giving a softer curd than magnesium chloride. It is also used as a dough conditioner and calcium source.",
  "derivation_summary": "Mined as gypsum and purified, or obtained as a by-product of industrial processes.",
  "regulatory_status": [
    {
      "jurisdiction": "US",
      "jurisdiction_name": "United States",
      "authority": "Food and Drug Administration",
      "status": "permitted",
      "status_label": "Permitted",
      "provision_count": 1,
      "provisions": [
        {
          "status": "permitted",
          "food_category": null,
          "max_level": null,
          "max_level_unit": null,
          "conditions": null,
          "effective_from": null,
          "citation": {
            "ref": "21 CFR 184.1230",
            "url": "https://www.ecfr.gov/current/title-21/section-184.1230"
          },
          "source": "ecfr",
          "retrieved_at": "2026-09-07T18:25:51.549Z"
        }
      ]
    },
    {
      "jurisdiction": "CODEX",
      "jurisdiction_name": "Codex Alimentarius",
      "authority": "Codex Alimentarius Commission / JECFA",
      "status": "permitted_with_conditions",
      "status_label": "Permitted, with conditions",
      "provision_count": 9,
      "provisions": [
        {
          "status": "permitted",
          "food_category": null,
          "max_level": null,
          "max_level_unit": "GMP",
          "conditions": null,
          "effective_from": "1999",
          "citation": {
            "ref": "CXS 192-1995 Table Three, INS 516",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "01.2.1.2",
            "name": "Fermented milks (plain), heat-treated after fermentation"
          },
          "max_level": null,
          "max_level_unit": "GMP",
          "conditions": "GSFA notes: 630",
          "effective_from": "2024",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 516, food category 01.2.1.2",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "01.4.1",
            "name": "Pasteurized cream (plain)"
          },
          "max_level": null,
          "max_level_unit": "GMP",
          "conditions": "GSFA notes: XS288",
          "effective_from": "2013",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 516, food category 01.4.1",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "01.4.2",
            "name": "Sterilized and UHT creams, whipping and whipped creams, and reduced fat creams (plain)"
          },
          "max_level": null,
          "max_level_unit": "GMP",
          "conditions": null,
          "effective_from": "2013",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 516, food category 01.4.2",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.2.2.1",
            "name": "Frozen vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweeds and nuts and seeds"
          },
          "max_level": null,
          "max_level_unit": "GMP",
          "conditions": "GSFA notes: 29, 323, 324 & 93",
          "effective_from": "2024",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 516, food category 04.2.2.1",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "06.2.1",
            "name": "Flours"
          },
          "max_level": null,
          "max_level_unit": "GMP",
          "conditions": "GSFA notes: 57 & 170",
          "effective_from": "2025",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 516, food category 06.2.1",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "06.4.2",
            "name": "Dried pastas and noodles and like products"
          },
          "max_level": null,
          "max_level_unit": "GMP",
          "conditions": "GSFA notes: 256",
          "effective_from": "2014",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 516, food category 06.4.2",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "10.2.1",
            "name": "Liquid egg products"
          },
          "max_level": null,
          "max_level_unit": "GMP",
          "conditions": null,
          "effective_from": "2015",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 516, food category 10.2.1",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "14.2.3.3",
            "name": "Fortified grape wine, grape liquor wine, and sweet grape wine"
          },
          "max_level": null,
          "max_level_unit": "GMP",
          "conditions": "GSFA notes: 517",
          "effective_from": "2023",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 516, food category 14.2.3.3",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        }
      ]
    }
  ],
  "names": [
    {
      "name": "7778-18-9",
      "type": "cas",
      "source": "openfoodtox"
    },
    {
      "name": "Anhydrite",
      "type": "common",
      "source": "openfoodtox"
    },
    {
      "name": "Anhydrous calcium sulfate",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Anhydrous gypsum",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Anhydrous sulfate of lime",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Anhydrous sulphate of lime",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Artificial Dental Stone",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Basic calcium sulfate",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calc Sulph",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calc Sulph 12X",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calc Sulph 14X",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calc Sulph 200X",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calc Sulph 30X",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calc Sulph 3X",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calc Sulph 6X",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcarea Sulfurica",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "CALCAREA SULPH",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcarea sulphurica",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcarea Sulphurica 200ck",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcarea sulphurica 30C",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcii sulfas",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcium (as sulfate)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcium salt of sulfuric acid",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "CALCIUM SULFATE",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcium sulfate (1:1)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcium sulfate (1:1) dihydrate",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcium sulfate (CaSO4)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcium sulfate, anhydrous",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calcium sulphate",
      "type": "common",
      "source": "openfoodtox"
    },
    {
      "name": "Calcium sulphate anhydrous",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "CALCIUM SULPHATE ANHYDROUS (E516)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Calmatrix",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "CAS 20",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Crysalba",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Dead-burned gypsum",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Denka sigma 1000",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Dental Stone, Artificial",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Drierite",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "E 516",
      "type": "common",
      "source": "openfoodtox"
    },
    {
      "name": "Franklin Fiber H 45",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "GIBS",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Gypsum",
      "type": "common",
      "source": "openfoodtox"
    },
    {
      "name": "Gypsum, Dental",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "INS NO.516",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "INS-516",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Insoluble anhydrite",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Karstenite",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Muriacite",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Native calcium sulphate",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Natural anhydrite",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Oparex 10",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Osteoset",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Precipitated calcium sulphate",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Raddichem 27",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Selenite",
      "type": "common",
      "source": "openfoodtox"
    },
    {
      "name": "Shi gao",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Shigao",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "SSS-A",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Stone paste",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Stone, Artificial Dental",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "SULFURIC ACID CALCIUM(2+) SALT (1:1)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Sulfuric acid, calcium salt (1:1)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Thiolite",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "TONICPET 3",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "E516",
      "type": "e_number",
      "source": "openfoodtox"
    },
    {
      "name": "516",
      "type": "ins",
      "source": "gsfa"
    },
    {
      "name": "Calcium sulfate",
      "type": "iupac",
      "source": "openfoodtox"
    },
    {
      "name": "Calcium sulfate",
      "type": "label",
      "source": "ecfr"
    }
  ],
  "hazard_reference_values": [],
  "sources": [
    {
      "key": "ecfr",
      "name": "Electronic Code of Federal Regulations, Title 21",
      "publisher": "U.S. Government Publishing Office / National Archives",
      "licence": "Public domain",
      "url": "https://www.ecfr.gov/api/versioner/v1/full/2026-08-31/title-21.xml",
      "retrieved_at": "2026-09-07T18:25:51.549Z"
    },
    {
      "key": "gsfa",
      "name": "Codex General Standard for Food Additives (CXS 192-1995)",
      "publisher": "Codex Alimentarius Commission (FAO/WHO)",
      "licence": "FAO terms — non-commercial use with attribution",
      "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/",
      "retrieved_at": "2026-09-07T07:54:15.059Z"
    }
  ],
  "citation_policy": "Cite as: Food Additive Index, \"Calcium sulfate\", https://foodadditiveindex.com/additives/calcium-sulfate. This site reports regulatory status and does not rate additives.",
  "generated_at": "2026-09-08T00:09:38.462Z"
}