{
  "$schema": "https://foodadditiveindex.com/api/v1/schema.json",
  "id": "https://foodadditiveindex.com/additives/disodium-guanylate",
  "slug": "disodium-guanylate",
  "name": "Disodium guanylate",
  "identifiers": {
    "e_number": "E627",
    "ins_number": "627",
    "cas_number": "5550-12-9",
    "inchikey": "PVBRXXAAPNGWGE-LGVAUZIVSA-L",
    "pubchem_cid": 135414246
  },
  "functional_class": "Flavour enhancer",
  "summary": "Disodium guanylate is a flavour enhancer used alongside MSG and inosinate, and is the reason a small amount of MSG can carry a whole seasoning.",
  "derivation_summary": "Produced by bacterial fermentation, though extraction from yeast or fish is also possible. The source is not usually declared, so a vegetarian cannot be certain from a label alone.",
  "regulatory_status": [
    {
      "jurisdiction": "US",
      "jurisdiction_name": "United States",
      "authority": "Food and Drug Administration",
      "status": "permitted_with_conditions",
      "status_label": "Permitted, with conditions",
      "provision_count": 1,
      "provisions": [
        {
          "status": "permitted_with_conditions",
          "food_category": null,
          "max_level": null,
          "max_level_unit": null,
          "conditions": null,
          "effective_from": null,
          "citation": {
            "ref": "21 CFR 172.530",
            "url": "https://www.ecfr.gov/current/title-21/section-172.530"
          },
          "source": "ecfr",
          "retrieved_at": "2026-09-07T18:25:51.549Z"
        }
      ]
    },
    {
      "jurisdiction": "CODEX",
      "jurisdiction_name": "Codex Alimentarius",
      "authority": "Codex Alimentarius Commission / JECFA",
      "status": "permitted_with_conditions",
      "status_label": "Permitted, with conditions",
      "provision_count": 11,
      "provisions": [
        {
          "status": "permitted",
          "food_category": null,
          "max_level": null,
          "max_level_unit": "GMP",
          "conditions": null,
          "effective_from": "1999",
          "citation": {
            "ref": "CXS 192-1995 Table Three, INS 627",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "04.2.2.7",
            "name": "Fermented vegetable (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera) and seaweed products, excluding fermented soybean products of food categories 06.8.6, 06.8.7, 12.9.1,"
          },
          "max_level": null,
          "max_level_unit": "GMP",
          "conditions": "GSFA notes: 279",
          "effective_from": "2025",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 627, food category 04.2.2.7",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "06.4.2",
            "name": "Dried pastas and noodles and like products"
          },
          "max_level": null,
          "max_level_unit": "GMP",
          "conditions": "GSFA notes: 256",
          "effective_from": "2014",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 627, food category 06.4.2",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "08.1",
            "name": "Fresh meat, poultry, and game"
          },
          "max_level": null,
          "max_level_unit": "GMP",
          "conditions": "GSFA notes: 16",
          "effective_from": "2014",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 627, food category 08.1",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "09.2.1",
            "name": "Frozen fish, fish fillets, and fish products, including molluscs, crustaceans, and echinoderms"
          },
          "max_level": null,
          "max_level_unit": "GMP",
          "conditions": "GSFA notes: 95, XS36, XS92, XS95, XS165, XS190, XS191, XS292, XS312 & XS315",
          "effective_from": "2017",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 627, food category 09.2.1",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "09.2.2",
            "name": "Frozen battered fish, fish fillets and fish products, including molluscs, crustaceans, and echinoderms"
          },
          "max_level": null,
          "max_level_unit": "GMP",
          "conditions": "GSFA notes: 309 & XS166",
          "effective_from": "2017",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 627, food category 09.2.2",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "09.2.3",
            "name": "Frozen minced and creamed fish products, including molluscs, crustaceans, and echinoderms"
          },
          "max_level": null,
          "max_level_unit": "GMP",
          "conditions": "GSFA notes: 311",
          "effective_from": "2015",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 627, food category 09.2.3",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "09.2.4",
            "name": "Cooked and/or fried fish and fish products, including molluscs, crustaceans, and echinoderms"
          },
          "max_level": null,
          "max_level_unit": "GMP",
          "conditions": "GSFA notes: 312",
          "effective_from": "2015",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 627, food category 09.2.4",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "09.2.5",
            "name": "Smoked, dried, fermented, and/or salted fish and fish products, including molluscs, crustaceans, and echinoderms"
          },
          "max_level": null,
          "max_level_unit": "GMP",
          "conditions": "GSFA notes: 29, XS167, XS189, XS222, XS236, XS244 & XS311",
          "effective_from": "2018",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 627, food category 09.2.5",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "12.1.2",
            "name": "Salt substitutes"
          },
          "max_level": null,
          "max_level_unit": "GMP",
          "conditions": null,
          "effective_from": "2015",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 627, food category 12.1.2",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        },
        {
          "status": "permitted_with_conditions",
          "food_category": {
            "system": "codex",
            "code": "14.1.5",
            "name": "Coffee, coffee substitutes, tea, herbal infusions, and other hot cereal and grain beverages, excluding cocoa"
          },
          "max_level": null,
          "max_level_unit": "GMP",
          "conditions": "GSFA notes: 201",
          "effective_from": "2015",
          "citation": {
            "ref": "CXS 192-1995 Table One, INS 627, food category 14.1.5",
            "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/"
          },
          "source": "gsfa",
          "retrieved_at": "2026-09-07T07:54:15.059Z"
        }
      ]
    }
  ],
  "names": [
    {
      "name": "111036-20-5",
      "type": "cas",
      "source": "pubchem"
    },
    {
      "name": "13474-02-7",
      "type": "cas",
      "source": "pubchem"
    },
    {
      "name": "550-12-9",
      "type": "cas",
      "source": "pubchem"
    },
    {
      "name": "5550-12-9",
      "type": "cas",
      "source": "openfoodtox"
    },
    {
      "name": "5'-GMP 2Na",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5'-Gmp disodium salt",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5'-Guanylic acid disodium salt",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5'-Guanylic acid, sodium salt (1:2)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5-Guanylic Acid .X Sodium Salt",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5-Guanylic acid disodium salt",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "ANHYDROUS DISODIUM GUANYLATE",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "CCRIS 6561",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "disodium 5'--guanylate",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Disodium 5'-gmp",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "DISODIUM 5'-GUANYLATE",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Disodium 5'-guanylate (VAN)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Disodium 5'-guanylate; 5'-GMP 2Na; 5'-Guanylic acid disodium salt",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "disodium 5'-O-phosphonatoguanosine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Disodium GMP",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Disodium guanos",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Disodium guanosine 5'-monophosphate",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Disodium guanosine-5'-monophosphate",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Disodium guanylate",
      "type": "common",
      "source": "openfoodtox"
    },
    {
      "name": "DISODIUM GUANYLATE (MART.)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "DISODIUM GUANYLATE (USP-RS)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "E 627",
      "type": "common",
      "source": "openfoodtox"
    },
    {
      "name": "FEMA No. 3668",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "GMP",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "GMP disodium salt",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "GMP sodium salt",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "GMP.Na2",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Guanosine 5 inverted exclamation marka-monophosphate disodium salt hydrate",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Guanosine 5'-monophosphate disodium salt",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Guanosine 5'-phosphate disodium salt",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Guanosine 5'MP, disodium salt",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Guanosine 5-Monophosphate Disodium Salt",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Guanosine-5'-monophosphate disodium salt",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Guanosine-5'phosphate disodium salt",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "GUANYLIC ACID DISODIUM",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Guanylic acid sodium salt",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "INS NO.627",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "INS-627",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "PVBRXXAAPNGWGE-LGVAUZIVSA-L",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Sodium 5'-guanylate",
      "type": "common",
      "source": "openfoodtox"
    },
    {
      "name": "Sodium GMP",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Sodium guanosine 5'-monophosphate",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Sodium guanylate",
      "type": "common",
      "source": "openfoodtox"
    },
    {
      "name": "Sodium guanylateSodium 5'-guanylate",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "E627",
      "type": "e_number",
      "source": "openfoodtox"
    },
    {
      "name": "627",
      "type": "ins",
      "source": "gsfa"
    },
    {
      "name": "[(3S,2R,4R,5R)-5-(2-amino-6-oxohydropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methy l dihydrogen phosphate, sodium salt, sodium salt",
      "type": "iupac",
      "source": "pubchem"
    },
    {
      "name": "disodium [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate",
      "type": "iupac",
      "source": "openfoodtox"
    },
    {
      "name": "disodium [(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate",
      "type": "iupac",
      "source": "pubchem"
    },
    {
      "name": "disodium;[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate",
      "type": "iupac",
      "source": "pubchem"
    },
    {
      "name": "sodium ((2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate",
      "type": "iupac",
      "source": "pubchem"
    },
    {
      "name": "Sodium ((2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate",
      "type": "iupac",
      "source": "pubchem"
    },
    {
      "name": "Disodium guanylate",
      "type": "label",
      "source": "ecfr"
    }
  ],
  "hazard_reference_values": [],
  "sources": [
    {
      "key": "ecfr",
      "name": "Electronic Code of Federal Regulations, Title 21",
      "publisher": "U.S. Government Publishing Office / National Archives",
      "licence": "Public domain",
      "url": "https://www.ecfr.gov/api/versioner/v1/full/2026-08-31/title-21.xml",
      "retrieved_at": "2026-09-07T18:25:51.549Z"
    },
    {
      "key": "gsfa",
      "name": "Codex General Standard for Food Additives (CXS 192-1995)",
      "publisher": "Codex Alimentarius Commission (FAO/WHO)",
      "licence": "FAO terms — non-commercial use with attribution",
      "url": "https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/gsfa/en/",
      "retrieved_at": "2026-09-07T07:54:15.059Z"
    }
  ],
  "citation_policy": "Cite as: Food Additive Index, \"Disodium guanylate\", https://foodadditiveindex.com/additives/disodium-guanylate. This site reports regulatory status and does not rate additives.",
  "generated_at": "2026-09-08T00:09:38.514Z"
}