{
  "$schema": "https://foodadditiveindex.com/api/v1/schema.json",
  "id": "https://foodadditiveindex.com/additives/folic-acid-folacin",
  "slug": "folic-acid-folacin",
  "name": "Folic acid (folacin)",
  "identifiers": {
    "e_number": null,
    "ins_number": null,
    "cas_number": "59-30-3",
    "inchikey": "OVBPIULPVIDEAO-LBPRGKRZSA-N",
    "pubchem_cid": 135398658
  },
  "functional_class": null,
  "summary": "Folic acid is the synthetic form of folate, added to flour in many countries specifically to reduce neural tube defects in pregnancy. It is one of the clearest public-health uses of a food additive.",
  "derivation_summary": "Produced by chemical synthesis. It is more stable and more readily absorbed than the folates naturally present in leafy vegetables, which is why the synthetic form is used for fortification.",
  "regulatory_status": [
    {
      "jurisdiction": "US",
      "jurisdiction_name": "United States",
      "authority": "Food and Drug Administration",
      "status": "permitted_with_conditions",
      "status_label": "Permitted, with conditions",
      "provision_count": 1,
      "provisions": [
        {
          "status": "permitted_with_conditions",
          "food_category": null,
          "max_level": null,
          "max_level_unit": null,
          "conditions": null,
          "effective_from": null,
          "citation": {
            "ref": "21 CFR 172.345",
            "url": "https://www.ecfr.gov/current/title-21/section-172.345"
          },
          "source": "ecfr",
          "retrieved_at": "2026-09-07T18:25:51.549Z"
        }
      ]
    },
    {
      "jurisdiction": "CODEX",
      "jurisdiction_name": "Codex Alimentarius",
      "authority": "Codex Alimentarius Commission / JECFA",
      "status": "not_listed",
      "status_label": "Not listed",
      "note": "Does not appear on this jurisdiction’s permitted list. That is not the same as being prohibited.",
      "provision_count": 0,
      "provisions": []
    }
  ],
  "names": [
    {
      "name": "59-30-3",
      "type": "cas",
      "source": "ecfr"
    },
    {
      "name": "4-Pteridinol, 2-amino-6-((p-((1,3-dicarboxypropyl)carbamoyl)anilino)methyl)-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "935E97BOY8",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Acfol (Spain)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Acide folique",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Acido folico",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Acidum folicum",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Acifolic",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Antianemia factor",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Bio Science",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Cytofol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Dosfolat B activ",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Facid",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Factor U",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "FOLACID",
      "type": "common",
      "source": "openfoodtox"
    },
    {
      "name": "Folacin",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Folaemin [Netherlands]",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Folasic (Australia)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Folbal",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Folcidin",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Foldine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Foldine (France)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Folettes",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Foliamin",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "folic acid",
      "type": "common",
      "source": "openfoodtox"
    },
    {
      "name": "Folicare",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Folicet",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Folico (Italy)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Folina (Italy)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Folipac",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Folsaeure",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Folsan",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Folsaure",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Folsav",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Folvite",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Glutamic acid, N-(p-(((2-amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-, l-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Incafolic",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Kyselina listova",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Lexpec",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Liver Lactobacillus casei factor",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Megafol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Millafol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "N-pteroyl-L-glutamic acid",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Natur Flow",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Nifolin [Denmark]",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Novofolacid [Canada]",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Preconceive",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "PteGlu",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Pteroyl-L-glutamic acid",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Pteroyl-L-monoglutamic acid",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Pteroylglutamic acid",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Pteroylmonoglutamic acid",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Usaf cb-13",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Vitamin B11",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Vitamin B9",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Vitamin Bc",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Vitamin Be",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Vitamin M",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L",
      "type": "iupac",
      "source": "pubchem"
    },
    {
      "name": "N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid",
      "type": "iupac",
      "source": "openfoodtox"
    },
    {
      "name": "Folic acid (folacin)",
      "type": "label",
      "source": "ecfr"
    }
  ],
  "hazard_reference_values": [],
  "sources": [
    {
      "key": "ecfr",
      "name": "Electronic Code of Federal Regulations, Title 21",
      "publisher": "U.S. Government Publishing Office / National Archives",
      "licence": "Public domain",
      "url": "https://www.ecfr.gov/api/versioner/v1/full/2026-08-31/title-21.xml",
      "retrieved_at": "2026-09-07T18:25:51.549Z"
    }
  ],
  "citation_policy": "Cite as: Food Additive Index, \"Folic acid (folacin)\", https://foodadditiveindex.com/additives/folic-acid-folacin. This site reports regulatory status and does not rate additives.",
  "generated_at": "2026-09-08T00:09:38.543Z"
}