{
  "$schema": "https://foodadditiveindex.com/api/v1/schema.json",
  "id": "https://foodadditiveindex.com/additives/morpholine",
  "slug": "morpholine",
  "name": "Morpholine",
  "identifiers": {
    "e_number": null,
    "ins_number": null,
    "cas_number": "110-91-8",
    "inchikey": "YNAVUWVOSKDBBP-UHFFFAOYSA-N",
    "pubchem_cid": 8083
  },
  "functional_class": null,
  "summary": "Morpholine is a component of the wax coatings applied to fresh fruit, acting as the agent that lets the wax emulsify in water.",
  "derivation_summary": "Produced by chemical synthesis from diethylene glycol and ammonia.",
  "regulatory_status": [
    {
      "jurisdiction": "US",
      "jurisdiction_name": "United States",
      "authority": "Food and Drug Administration",
      "status": "permitted_with_conditions",
      "status_label": "Permitted, with conditions",
      "provision_count": 1,
      "provisions": [
        {
          "status": "permitted_with_conditions",
          "food_category": null,
          "max_level": null,
          "max_level_unit": null,
          "conditions": null,
          "effective_from": null,
          "citation": {
            "ref": "21 CFR 172.235",
            "url": "https://www.ecfr.gov/current/title-21/section-172.235"
          },
          "source": "ecfr",
          "retrieved_at": "2026-09-07T18:25:51.549Z"
        }
      ]
    },
    {
      "jurisdiction": "CODEX",
      "jurisdiction_name": "Codex Alimentarius",
      "authority": "Codex Alimentarius Commission / JECFA",
      "status": "not_listed",
      "status_label": "Not listed",
      "note": "Does not appear on this jurisdiction’s permitted list. That is not the same as being prohibited.",
      "provision_count": 0,
      "provisions": []
    }
  ],
  "names": [
    {
      "name": "110-91-8",
      "type": "cas",
      "source": "openfoodtox"
    },
    {
      "name": "138048-80-3",
      "type": "cas",
      "source": "pubchem"
    },
    {
      "name": "1-Oxa-4-azacyclohexane",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1-Oxa-4-azacyclohexane; Tetrahydro-2H-1,4-oxazine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "2H-1,4-Oxazine, tetrahydro-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "4-27-00-00015 (Beilstein Handbook Reference)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "4H-1, tetrahydro-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "4H-1,4-Oxazine, tetrahydro-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "8B2ZCK305O",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "BASF 238",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "BRN 0102549",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "CAS-110-91-8",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Caswell No. 584",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "CCRIS 2482",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Diethylene imidoxide",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Diethylene oximide",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Diethyleneimide oxide",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Diethylenimide oxide",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Drewamine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "EPA Pesticide Chemical Code 054701",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "HSDB 102",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "InChI=1/C4H9NO/c1-3-6-4-2-5-1/h5H,1-4H",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Molsidomine EP Impurity E",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "morphline",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "morpho line",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "morpholin",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Morpholine",
      "type": "common",
      "source": "openfoodtox"
    },
    {
      "name": "Morpholine (BASF)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Morpholine on Rasta Resin",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Morpholine purified by distillation from glass",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Morpholine(Discontinued,See C4X-20707)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Morpholine, ACS reagent, >=99.0%",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Morpholine, analytical standard",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Morpholine, p.a., ACS reagent, 99.0%",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "MORPHOLINE, PRACT",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Morpholine, purified by redistillation, >=99.5%",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Morpholine, ReagentPlus(R), >=99%",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "MORPHOLINE,REAG",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "morpholine-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Morpholine; Molsidomine Imp. E (EP); Molsidomine Impurity E",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "p-Isoxazine, tetrahydro-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Polymer bonded morpholine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Tetrahydro-1,4-isoxazine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Tetrahydro-1,4-oxazine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Tetrahydro-2H-1,4-oxazine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Tetrahydro-4H-1,4-Oxazine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Tetrahydro-4H-1-4-oxazine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Tetrahydro-p-isoxazine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Tetrahydro-p-oxazine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Tetryhydro-2H-1,4-oxazine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "WLN: T6M DOTJ",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "morpholine",
      "type": "iupac",
      "source": "openfoodtox"
    },
    {
      "name": "ScavengePore(TM) phenethyl morpholine, macroporous, 40-70 mesh, extent of labeling: 0.7-1.5 mmol/g loading",
      "type": "iupac",
      "source": "pubchem"
    },
    {
      "name": "StratoSpheres(TM) PL-MPH resin, 50-100 mesh, extent of labeling: 3.0-4.0 mmol/g loading, 1 % cross-linked",
      "type": "iupac",
      "source": "pubchem"
    },
    {
      "name": "Morpholine",
      "type": "label",
      "source": "ecfr"
    }
  ],
  "hazard_reference_values": [
    {
      "type": "ADI",
      "value": null,
      "value_text": "1",
      "unit": null,
      "population": "consumers",
      "assessing_body": "EFSA",
      "year": 2023,
      "opinion": {
        "ref": "doi: 10.2903/j.efsa.2023.8032",
        "url": "https://doi.org/10.2903/j.efsa.2023.8032"
      }
    }
  ],
  "sources": [
    {
      "key": "ecfr",
      "name": "Electronic Code of Federal Regulations, Title 21",
      "publisher": "U.S. Government Publishing Office / National Archives",
      "licence": "Public domain",
      "url": "https://www.ecfr.gov/api/versioner/v1/full/2026-08-31/title-21.xml",
      "retrieved_at": "2026-09-07T18:25:51.549Z"
    }
  ],
  "citation_policy": "Cite as: Food Additive Index, \"Morpholine\", https://foodadditiveindex.com/additives/morpholine. This site reports regulatory status and does not rate additives.",
  "generated_at": "2026-09-08T00:09:38.605Z"
}