{
  "$schema": "https://foodadditiveindex.com/api/v1/schema.json",
  "id": "https://foodadditiveindex.com/additives/nordihydroguaiaretic-acid-ndga",
  "slug": "nordihydroguaiaretic-acid-ndga",
  "name": "Nordihydroguaiaretic acid (NDGA)",
  "identifiers": {
    "e_number": null,
    "ins_number": null,
    "cas_number": null,
    "inchikey": "HCZKYJDFEPMADG-UHFFFAOYSA-N",
    "pubchem_cid": 4534
  },
  "functional_class": null,
  "summary": "NDGA is an antioxidant obtained from the creosote bush and was used to stop fats going rancid. The FDA removed it from the GRAS list and prohibited it after animal studies reported kidney damage.",
  "derivation_summary": "Extracted from the leaves and twigs of the creosote bush, Larrea tridentata, of the south-western United States and Mexico. It can also be synthesised.",
  "regulatory_status": [
    {
      "jurisdiction": "US",
      "jurisdiction_name": "United States",
      "authority": "Food and Drug Administration",
      "status": "prohibited",
      "status_label": "Prohibited",
      "provision_count": 1,
      "provisions": [
        {
          "status": "prohibited",
          "food_category": null,
          "max_level": null,
          "max_level_unit": null,
          "conditions": null,
          "effective_from": null,
          "citation": {
            "ref": "21 CFR 189.165",
            "url": "https://www.ecfr.gov/current/title-21/section-189.165"
          },
          "source": "ecfr",
          "retrieved_at": "2026-09-07T18:25:51.549Z"
        }
      ]
    },
    {
      "jurisdiction": "CODEX",
      "jurisdiction_name": "Codex Alimentarius",
      "authority": "Codex Alimentarius Commission / JECFA",
      "status": "not_listed",
      "status_label": "Not listed",
      "note": "Does not appear on this jurisdiction’s permitted list. That is not the same as being prohibited.",
      "provision_count": 0,
      "provisions": []
    }
  ],
  "names": [
    {
      "name": "500-38-9",
      "type": "cas",
      "source": "pubchem"
    },
    {
      "name": ".beta.,.delta.-bis(3,4-dihydroxyphenyl)butane",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": ".beta.,.gamma.-Dimethyl-.alpha.,.delta.-bis(3,4-dihydroxyphenyl)butane",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethyl-butan",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "2,3-bis(3,4-dihydroxybenzyl)butane",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "2,3-Bis(3,4-dihydroxyphenylmethyl)butane",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "2,3-Dimethyl-1,4-bis(3,4-dihydroxyphenyl)butane",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "4,3-Dimethyl-1,4-butanediyl)bis(pyrocatechol)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "4,3-Dimethyltetramethylene)dipyrocatechol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "4,4'-(2,3-Dimethyl-1,4-butanediyl)bis(pyrocatechol)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "4,4'-(2,3-Dimethyl-1,4-butanediyl)bis-1,2-benzenediol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "4,4'-(2,3-dimethylbutane-1,4-diyl)bis(benzene-1,2-diol)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "4,4'-(2,3-Dimethylbutane-1,4-diyl)di(benzene-1,2-diol)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "4,4'-(2,3-dimethylbutane-1,4-diyl)dibenzene-1,2-diol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "4,4'-(2,3-Dimethyltetramethyl-ene)dipyrocatechol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]benzene-1,2-diol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyrocatechol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "4-[4-[3,4-bis(oxidanyl)phenyl]-2,3-dimethyl-butyl]benzene-1,2-diol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "beta,gamma-Dimethyl-alpha,delta-bis(3,4-dihydroxyphenyl)butane",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Butane, 1,4-bis(3,4-dihydroxyphenyl)-2,3-dimethyl-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Butane,4-bis(3,4-dihydroxyphenyl)-2,3-dimethyl-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "CAS-500-38-9",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "CCRIS 1399",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "CHX 100; Masoprocol; meso-NDGA",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Dinorguaia",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "HCZKYJDFEPMADG-UHFFFAOYSA-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "HMS503G19",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "LOX inhibitor, N/A",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "NDGA",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Nordihydro Guaiaretic Acid (mixture of diastereomers)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "nordihydroguaiaretate",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "NORDIHYDROGUAIARETIC ACID",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "nordihydroguaiaretic acid (ndga)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Nordihydroguaiaretic acid (Standard)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Nordihydroguaiaretic acid - mixture of diastereomers",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Nordihydroguaiaretic acid, >=90% (HPLC), from Larrea divaricata (creosote bush)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Nordihydroguaiaretic acid, >=97.0% (HPLC)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "NordihydroGuaiareticAcid-d6",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "nordihydroguajaretic acid",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "nordihydroguaretic acid",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Norguaiaretic acid, dihydro",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Norguaiaretic acid, dihydro-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Norhydroguaiaretic acid",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Pyrocatechol, 4,4'-(2,3-dimethyltetramethylene)di-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "PYROCATECHOL,4'- (2,3-DIEMTHYLTETRAMETHYLENE) DI-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Pyrocatechol,4'-(2,3-dimethyltetramethylene)di-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "WLN: QR BQ D1Y1&Y1&1R CQ DQ",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "InChI=1/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3",
      "type": "iupac",
      "source": "pubchem"
    },
    {
      "name": "Nordihydroguaiaretic acid; 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis[1,2-benzenediol]",
      "type": "iupac",
      "source": "pubchem"
    },
    {
      "name": "Nordihydroguaiaretic acid (NDGA)",
      "type": "label",
      "source": "ecfr"
    }
  ],
  "hazard_reference_values": [],
  "sources": [
    {
      "key": "ecfr",
      "name": "Electronic Code of Federal Regulations, Title 21",
      "publisher": "U.S. Government Publishing Office / National Archives",
      "licence": "Public domain",
      "url": "https://www.ecfr.gov/api/versioner/v1/full/2026-08-31/title-21.xml",
      "retrieved_at": "2026-09-07T18:25:51.549Z"
    }
  ],
  "citation_policy": "Cite as: Food Additive Index, \"Nordihydroguaiaretic acid (NDGA)\", https://foodadditiveindex.com/additives/nordihydroguaiaretic-acid-ndga. This site reports regulatory status and does not rate additives.",
  "generated_at": "2026-09-08T00:09:38.613Z"
}