{
  "$schema": "https://foodadditiveindex.com/api/v1/schema.json",
  "id": "https://foodadditiveindex.com/additives/p-4000",
  "slug": "p-4000",
  "name": "P-4000",
  "identifiers": {
    "e_number": null,
    "ins_number": null,
    "cas_number": null,
    "inchikey": "RXQCEGOUSFBKPI-UHFFFAOYSA-N",
    "pubchem_cid": 11118
  },
  "functional_class": null,
  "summary": "P-4000 was an artificial sweetener roughly four thousand times as sweet as sugar, which is where the name comes from. The FDA prohibited it in 1950, in the same period it acted against dulcin, and it has had no food use since.",
  "derivation_summary": "A synthetic aromatic compound, 5-nitro-2-propoxyaniline, made from petroleum-derived starting materials. It is of historical interest only; nothing in the food supply contains it.",
  "regulatory_status": [
    {
      "jurisdiction": "US",
      "jurisdiction_name": "United States",
      "authority": "Food and Drug Administration",
      "status": "prohibited",
      "status_label": "Prohibited",
      "provision_count": 1,
      "provisions": [
        {
          "status": "prohibited",
          "food_category": null,
          "max_level": null,
          "max_level_unit": null,
          "conditions": null,
          "effective_from": null,
          "citation": {
            "ref": "21 CFR 189.175",
            "url": "https://www.ecfr.gov/current/title-21/section-189.175"
          },
          "source": "ecfr",
          "retrieved_at": "2026-09-07T18:25:51.549Z"
        }
      ]
    },
    {
      "jurisdiction": "CODEX",
      "jurisdiction_name": "Codex Alimentarius",
      "authority": "Codex Alimentarius Commission / JECFA",
      "status": "not_listed",
      "status_label": "Not listed",
      "note": "Does not appear on this jurisdiction’s permitted list. That is not the same as being prohibited.",
      "provision_count": 0,
      "provisions": []
    }
  ],
  "names": [
    {
      "name": "553-79-7",
      "type": "cas",
      "source": "pubchem"
    },
    {
      "name": "1-n-Propoxy-2-amino-4-nitrobenzene",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1-Oxy-2-amino-4-nitrobenzol propyl aether",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1-Propoxy-2-amino-4-nitrobenzene",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1-Propoxy-2-amino-4-nitrobenzol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "2-Amino-4-nitro-1-n-propoxybenzene",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "2-Amino-4-nitro-1-propoxybenzene",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5-Nitro-2-n-propoxyaniline",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5-NITRO-2-PROPOXY ANILINE",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5-Nitro-2-propoxy-Aniline",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5-Nitro-2-propoxy-Benzenamine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5-Nitro-2-propoxy-phenylamine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5-Nitro-2-propoxyaniline",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5-Nitro-2-propoxybenzenamine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5-Nitro-2-propoxyphenylamine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "ANILINE, 5-NITRO-2-PROPOXY-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Aros X",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Aros-X",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Benzenamine, 5-nitro-2-propoxy-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Benzenamine, 5-nitro-2-propoxy- (9CI)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "BRN 2098543",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "HDS42MR6BM",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "P 4000 (Sweetener)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Sweetening agent P 4000",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Sweetening Agent P-4000",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Ultrasuess",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Ultrasuss",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Ultrasweet",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "P-4000",
      "type": "label",
      "source": "ecfr"
    }
  ],
  "hazard_reference_values": [],
  "sources": [
    {
      "key": "ecfr",
      "name": "Electronic Code of Federal Regulations, Title 21",
      "publisher": "U.S. Government Publishing Office / National Archives",
      "licence": "Public domain",
      "url": "https://www.ecfr.gov/api/versioner/v1/full/2026-08-31/title-21.xml",
      "retrieved_at": "2026-09-07T18:25:51.549Z"
    }
  ],
  "citation_policy": "Cite as: Food Additive Index, \"P-4000\", https://foodadditiveindex.com/additives/p-4000. This site reports regulatory status and does not rate additives.",
  "generated_at": "2026-09-08T00:09:38.617Z"
}