{
  "$schema": "https://foodadditiveindex.com/api/v1/schema.json",
  "id": "https://foodadditiveindex.com/additives/quinine",
  "slug": "quinine",
  "name": "Quinine",
  "identifiers": {
    "e_number": null,
    "ins_number": null,
    "cas_number": "130-95-0",
    "inchikey": "LOUPRKONTZGTKE-WZBLMQSHSA-N",
    "pubchem_cid": 3034034
  },
  "functional_class": null,
  "summary": "Quinine is the bitter compound in tonic water, permitted only in soft drinks and only at low levels. It is also an antimalarial drug, which is how tonic water began: as a way of taking the medicine.",
  "derivation_summary": "Extracted from the bark of the cinchona tree, or produced synthetically. The food limit is far below any medicinal dose.",
  "regulatory_status": [
    {
      "jurisdiction": "US",
      "jurisdiction_name": "United States",
      "authority": "Food and Drug Administration",
      "status": "permitted_with_conditions",
      "status_label": "Permitted, with conditions",
      "provision_count": 1,
      "provisions": [
        {
          "status": "permitted_with_conditions",
          "food_category": null,
          "max_level": null,
          "max_level_unit": null,
          "conditions": null,
          "effective_from": null,
          "citation": {
            "ref": "21 CFR 172.575",
            "url": "https://www.ecfr.gov/current/title-21/section-172.575"
          },
          "source": "ecfr",
          "retrieved_at": "2026-09-07T18:25:51.549Z"
        }
      ]
    },
    {
      "jurisdiction": "CODEX",
      "jurisdiction_name": "Codex Alimentarius",
      "authority": "Codex Alimentarius Commission / JECFA",
      "status": "not_listed",
      "status_label": "Not listed",
      "note": "Does not appear on this jurisdiction’s permitted list. That is not the same as being prohibited.",
      "provision_count": 0,
      "provisions": []
    }
  ],
  "names": [
    {
      "name": "130-95-0",
      "type": "cas",
      "source": "openfoodtox"
    },
    {
      "name": "72402-53-0",
      "type": "cas",
      "source": "pubchem"
    },
    {
      "name": "(-)-Quinine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "(-)quinine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "(1R)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "(8-alpha,9R)-6'-Methoxycinchonan-9-ol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "(8.alpha.,9R)-6'-Methoxycinchonan-9-ol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "(8S,9R)-6'-Methoxycinchonan-9-ol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "(8S,9R)-Quinine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "(9R)-6'-Methoxy-3alpha,8alpha-cinchonan-9-ol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "(9R)-6'-methoxy-8alpha-cinchonan-9-ol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "(R)-(-)-quinine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "(R)-(-)-Quinine, 6-methoxycinchonidine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "(R)-(6-methoxy-4-quinolyl)-[(2S,4S,5R)-5-vinylquinuclidin-2-yl]methanol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "(R)-(6-Methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "(R)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methanol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "2-Quinuclidinemethanol, alpha-(6-methoxy-4-quinolyl)-5-vinyl-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "6'-Methoxycinchonan-9-ol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "6'-Methoxycinchonidine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "6'-Methoxycinchonine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "6-Methoxycinchonine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "A7V27PHC7A",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Aflukin",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Biquinate (*Bisulfate heptathydrate*)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "CAS-130-95-0",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "CCRIS 5755",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Chinin",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Chinine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "chininum",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Chininum purum",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Cinchonan-9-ol, 6'-methoxy-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Cinchonan-9-ol, 6'-methoxy-, (8.alpha.,9R)-, sulfate",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Cinchonan-9-ol, 6'-methoxy-, (8a,9R)-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Dentojel (*Bisulfate heptathydrate*)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Epitope ID:131786",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "GNF-Pf-506",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "HSDB 2501",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Hydrochloride, Quinine",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Quinamm (*2:1 Sulfate salt*), dihydrate",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Quine (*2:1 Sulfate salt*, dihydrate)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Quinidine Sulfate EP Impurity A",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "quinina",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Quinine",
      "type": "common",
      "source": "openfoodtox"
    },
    {
      "name": "Quinine (Standard)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "quinine bisulphate",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Quinine, 90%",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Quinine, Anhydrous",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Quinine, tannate",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Quinineanhydrous",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Quinoline alkaloid",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Quinsan",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Quinsan (*2:1 Sulfate salt*), dihydrate",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Quinson",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Quinsul",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Rezquin",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "(5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl)-(6-methoxyquinolin-4-yl)methanol",
      "type": "iupac",
      "source": "openfoodtox"
    },
    {
      "name": "(R)-((4S,5R,7S)-5-ethenyl-1-azabicyclo(2.2.2)octan-7-yl)-(6-methoxyquinolin-4-yl)methanol",
      "type": "iupac",
      "source": "pubchem"
    },
    {
      "name": "(R)-[(1S,2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol",
      "type": "iupac",
      "source": "pubchem"
    },
    {
      "name": "(R)-[(2S,4S,5R)-1-Aza-5-vinylbicyclo[2.2.2]oct-2-yl](6-methoxyquinolin-4-yl)methanol",
      "type": "iupac",
      "source": "pubchem"
    },
    {
      "name": "(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol",
      "type": "iupac",
      "source": "pubchem"
    },
    {
      "name": "(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol",
      "type": "iupac",
      "source": "pubchem"
    },
    {
      "name": "Quinine",
      "type": "label",
      "source": "ecfr"
    }
  ],
  "hazard_reference_values": [],
  "sources": [
    {
      "key": "ecfr",
      "name": "Electronic Code of Federal Regulations, Title 21",
      "publisher": "U.S. Government Publishing Office / National Archives",
      "licence": "Public domain",
      "url": "https://www.ecfr.gov/api/versioner/v1/full/2026-08-31/title-21.xml",
      "retrieved_at": "2026-09-07T18:25:51.549Z"
    }
  ],
  "citation_policy": "Cite as: Food Additive Index, \"Quinine\", https://foodadditiveindex.com/additives/quinine. This site reports regulatory status and does not rate additives.",
  "generated_at": "2026-09-08T00:09:38.668Z"
}