{
  "$schema": "https://foodadditiveindex.com/api/v1/schema.json",
  "id": "https://foodadditiveindex.com/additives/safrole",
  "slug": "safrole",
  "name": "Safrole",
  "identifiers": {
    "e_number": null,
    "ins_number": null,
    "cas_number": "94-59-7",
    "inchikey": "ZMQAAUBTXCXRIC-UHFFFAOYSA-N",
    "pubchem_cid": 5144
  },
  "functional_class": null,
  "summary": "Safrole is the principal component of sassafras oil and was once used to flavour root beer. The FDA prohibited it as a food additive after studies in rodents reported liver tumours.",
  "derivation_summary": "Extracted from the root bark of sassafras and from other plant oils including camphor and star anise. Sassafras preparations from which safrole has been removed are treated separately from safrole itself in regulation.",
  "regulatory_status": [
    {
      "jurisdiction": "US",
      "jurisdiction_name": "United States",
      "authority": "Food and Drug Administration",
      "status": "prohibited",
      "status_label": "Prohibited",
      "provision_count": 1,
      "provisions": [
        {
          "status": "prohibited",
          "food_category": null,
          "max_level": null,
          "max_level_unit": null,
          "conditions": null,
          "effective_from": null,
          "citation": {
            "ref": "21 CFR 189.180",
            "url": "https://www.ecfr.gov/current/title-21/section-189.180"
          },
          "source": "ecfr",
          "retrieved_at": "2026-09-07T18:25:51.549Z"
        }
      ]
    },
    {
      "jurisdiction": "CODEX",
      "jurisdiction_name": "Codex Alimentarius",
      "authority": "Codex Alimentarius Commission / JECFA",
      "status": "not_listed",
      "status_label": "Not listed",
      "note": "Does not appear on this jurisdiction’s permitted list. That is not the same as being prohibited.",
      "provision_count": 0,
      "provisions": []
    }
  ],
  "names": [
    {
      "name": "94-59-7",
      "type": "cas",
      "source": "openfoodtox"
    },
    {
      "name": "(1,2-(Methylenedioxy)-4-allyl)benzene",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "(Allyldioxy)benzene methylene ether",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1, 5-(2-propenyl)-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1, 5-allyl-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1,2-methylenedioxy-4-allyl-Benzene",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1,2-Methylenedioxy-4-allylbenzene",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1,3-Benzodioxole, 5-(2-propen-1-yl)-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1,3-Benzodioxole, 5-(2-propenyl)-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1,3-Benzodioxole, 5-allyl-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1-Allyl-3,4-(methylenedioxy)benzene",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "1-Allyl-3,4-methylenedioxybenzene",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "3,4-(Methylenedioxy)allylbenzene",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "3,4-Methylenedioxy-allybenzene",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "3,4-methylenedioxy-allylbenzene",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "3-(3,4-Methylenedioxyphenyl)prop-1-ene",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "3-[(3,4-Methylenedioxy)phenyl]-1-propene",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "4 Allyl 1,2 methylenedioxybenzene",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "4-Allyl-1,2-(methylenedioxy)benzene",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "4-Allyl-1,2-methylenedioxybenzene",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "4-Allyl-1,2-methylenedioxybenzenes",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "4-Allylpyrocatechol formaldehyde acetal",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5-(2-Propenyl)-1,3-benzodioxole",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5-(prop-2-en-1-yl)-2H-1,3-benzodioxole",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5-19-01-00553 (Beilstein Handbook Reference)",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5-?Allyl-?1,3-?benzodioxole",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5-Allyl-1,3-benzodioxole",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5-allyl-benzo-1,3-dioxole",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5-allyl-benzo[1,3]dioxole",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5-allylbenzo[d][1,3]dioxole",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5-prop-2-enyl-1,3-benzodioxole",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Alda-89",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Allylcatechol methylene ether",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Allyldioxybenzene methylene ether",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Allylpyrocatechol methylene ether",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Benzene, 1,2-methylenedioxy-4-allyl-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Benzene, 4-allyl-1,2-(methylenedioxy)-",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "BRN 0136380",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "CAS-94-59-7",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Caswell No. 729",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "CCRIS 553",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "EPA Pesticide Chemical Code 097901",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "HSDB 2653",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "m-Allylpyrocatechin methylene ether",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "RCRA waste no. U203",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "RCRA waste number U203",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "saffrole",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Safrene",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Safrol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Safrole",
      "type": "common",
      "source": "openfoodtox"
    },
    {
      "name": "Safrole MF",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Safrole, 10mg/ml in Methanol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Safrole, >=97%",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Safroles",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Safrols",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Sassafras",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Shikimol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Shikimole",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Shikimols",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "Shikomol",
      "type": "common",
      "source": "pubchem"
    },
    {
      "name": "5-prop-2-enyl-1,3-benzodioxole",
      "type": "iupac",
      "source": "openfoodtox"
    },
    {
      "name": "Safrole",
      "type": "label",
      "source": "ecfr"
    }
  ],
  "hazard_reference_values": [],
  "sources": [
    {
      "key": "ecfr",
      "name": "Electronic Code of Federal Regulations, Title 21",
      "publisher": "U.S. Government Publishing Office / National Archives",
      "licence": "Public domain",
      "url": "https://www.ecfr.gov/api/versioner/v1/full/2026-08-31/title-21.xml",
      "retrieved_at": "2026-09-07T18:25:51.549Z"
    }
  ],
  "citation_policy": "Cite as: Food Additive Index, \"Safrole\", https://foodadditiveindex.com/additives/safrole. This site reports regulatory status and does not rate additives.",
  "generated_at": "2026-09-08T00:09:38.673Z"
}