Riboflavin 5'-phosphate sodium

INS 101(ii)

Used as a colour.

This is the Codex listing for riboflavin-5'-phosphate sodium, the water-soluble form of vitamin B2, used as a nutrient and as a yellow colour.

Where it is and isn’t permitted

Status of Riboflavin 5'-phosphate sodium by jurisdiction. Every jurisdiction this site covers is listed, including those where the substance does not appear.
JurisdictionStatusScope and limitsCitation
United StatesFood and Drug AdministrationNot listedDoes not appear on this jurisdiction’s permitted list. That is not the same as being prohibited.
Codex AlimentariusCodex Alimentarius Commission / JECFAPermitted, with conditions

13 food categories

no numerical limit (good manufacturing practice)

Show every food category
  • 04.1.1.2 Surface-treated fresh fruit — GMP
  • 04.2.1.2 Surface-treated fresh vegetables, (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweeds and nuts and seeds — GMP
  • 04.2.2.7 Fermented vegetable (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera) and seaweed products, excluding fermented soybean products of food categories 06.8.6, 06.8.7, 12.9.1, — GMP
  • 09.2.1 Frozen fish, fish fillets, and fish products, including molluscs, crustaceans, and echinoderms — GMP
  • 09.2.2 Frozen battered fish, fish fillets and fish products, including molluscs, crustaceans, and echinoderms — GMP
  • 09.2.3 Frozen minced and creamed fish products, including molluscs, crustaceans, and echinoderms — GMP
  • 09.2.4.1 Cooked fish and fish products — GMP
  • 09.2.4.2 Cooked molluscs, crustaceans, and echinoderms — GMP
  • 09.2.4.3 Fried fish and fish products, including molluscs, crustaceans, and echinoderms — GMP
  • 09.2.5 Smoked, dried, fermented, and/or salted fish and fish products, including molluscs, crustaceans, and echinoderms — GMP
  • 10.1 Fresh eggs — GMP
  • 11.3 Sugar solutions and syrups, also (partially) inverted, including treacle and molasses, excluding products of food category 1.1.1.3 — GMP
  • 11.4 Other sugars and syrups (e.g. xylose, maple syrup, sugar toppings) — GMP
CXS 192-1995 Table Three, INS 101(ii)and 13 further provisionsretrieved 2026-09-07

What it is made from

Made by phosphorylating riboflavin, itself produced by fermentation or synthesis.

  • Vegan
  • Vegetarian
InChIKey
LQVGUKOCMOKKJU-QPVGXXQTSA-M
PubChem
CID 23687712

Every name it appears under

49 recorded names. A label may use any of them.

INS number

  • 101(ii)

Other names

  • COLLAGEX-HYPOTONIC COMPONENT RIBOFLAVIN 5'-PHOSPHATE SODIUM
  • COLLAGEX-RAPID COMPONENT RIBOFLAVIN 5'-PHOSPHATE SODIUM
  • EPIOXA
  • EPIOXA HD/EPIOXA KIT
  • Flavin mononucleotide dihydrate
  • Flavin Mononucleotide Monosodium Salt, Dihydrate
  • FMN-Na
  • FMN-Na;Riboflavin 5'-phosphate sodium;Vitamin B2 Phosphate Sodium Salt
  • INS NO.101(II)
  • INS-101(II)
  • Phosphated riboflavin
  • PHOSPHATED RIBOFLAVIN (USP-RS)
  • Photrexa
  • Photrexa (TN)
  • PHOTREXA VISCOUS
  • Photrexa Viscous In Dextran 20%
  • PHOTREXA VISCOUS IN DEXTRAN 20%/PHOTREXA
  • Riboflavin (phosphate sodium)
  • Riboflavin 5 inverted exclamation marka-monophosphate sodium salt hydrate
  • Riboflavin 5'-(Dihydrogen Phosphate) Monosodium Salt Dihydrate (>80per cent)
  • Riboflavin 5'-(Dihydrogen Phosphate) Monosodium Salt Dihydrate (~70%)
  • Riboflavin 5'-(dihydrogen phosphate), monosodium salt, dihydrate
  • RIBOFLAVIN 5'-(DIHYDROGEN PHOSPHATE), SODIUM SALT, HYDRATE (1:1:2)
  • Riboflavin 5'-phosphate sodium
  • RIBOFLAVIN 5'-PHOSPHATE SODIUM (USP MONOGRAPH)
  • Riboflavin 5'-phosphate sodium (USP)
  • Riboflavin 5'-phosphate sodium component of collagex-hypotonic
  • Riboflavin 5'-phosphate sodium component of collagex-rapid
  • Riboflavin 5'-phosphate sodium salt dihydrate
  • Riboflavin 5'-phosphate sodium salt dihydrate, USP grade
  • Riboflavin 5?monophosphate Sodium Salt Hydrate
  • riboflavin 5\'-phosphate sodium anhydrous
  • riboflavin sodium phosphate
  • Riboflavin sodium phosphate dihydrate
  • Riboflavin-5 inverted exclamation mark -phosphate Sodium Salt Dihydrate
  • Riboflavin-5'-phosphate sodium salt dihydrate
  • Riboflavin-5'-phosphate sodium salt dihydrate, AldrichCPR
  • Riboflavin-5-phosphoric acid monosodium dihydrate
  • Riboflavine 5'-(sodium hydrogen phosphate), dihydrate
  • Riboflavine phosphate (sodium hydrate)
  • Riboflavine-5'-monophosphate sodium salt hydrate
  • Sodium riboflavin 5'-phosphate
  • SODIUM RIBOFLAVIN 5'-PHOSPHATE DIHYDRATE
  • Sodium Riboflavin Phosphate
  • Vitamin B2 phosphate (sodium salt) dihydrate

Systematic names

  • sodium (2R,3S,4S)-5-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-2,3,4-trihydroxypentyl hydrogen phosphate dihydrate
  • sodium (2R,3S,4S)-5-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-2,3,4-trihydroxypentyl hydrogenphosphate dihydrate
  • sodium;[(2R,3S,4S)-5-(7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10-yl)-2,3,4-trihydroxypentyl] hydrogen phosphate;dihydrate

Hazard reference values

No reference value for this substance in the sources we hold.

Evidence and how bodies read it

Studies, and the differing conclusions regulators drew from them, are curated by hand rather than machine-read, and none has been written for this substance yet.

Sources for this page

  • gsfa retrieved 2026-09-07

Full licence terms and publisher details on Sources. How this page is built and updated: Method.

Machine-readable:/api/v1/additives/riboflavin-5-phosphate-sodium-ins-101-ii-.json