Quinine

CAS 130-95-0

Quinine is the bitter compound in tonic water, permitted only in soft drinks and only at low levels. It is also an antimalarial drug, which is how tonic water began: as a way of taking the medicine.

Where it is and isn’t permitted

Status of Quinine by jurisdiction. Every jurisdiction this site covers is listed, including those where the substance does not appear.
JurisdictionStatusScope and limitsCitation
United StatesFood and Drug AdministrationPermitted, with conditions21 CFR 172.575retrieved 2026-09-07
Codex AlimentariusCodex Alimentarius Commission / JECFANot listedDoes not appear on this jurisdiction’s permitted list. That is not the same as being prohibited.

What it is made from

Extracted from the bark of the cinchona tree, or produced synthetically. The food limit is far below any medicinal dose.

  • Vegan
  • Vegetarian
CAS registry number
130-95-0
InChIKey
LOUPRKONTZGTKE-WZBLMQSHSA-N
PubChem
CID 3034034

Every name it appears under

62 recorded names. A label may use any of them.

CAS registry number

  • 130-95-0
  • 72402-53-0

As it appears in regulation

  • Quinine

Other names

  • (-)-Quinine
  • (-)quinine
  • (1R)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol
  • (8-alpha,9R)-6'-Methoxycinchonan-9-ol
  • (8.alpha.,9R)-6'-Methoxycinchonan-9-ol
  • (8S,9R)-6'-Methoxycinchonan-9-ol
  • (8S,9R)-Quinine
  • (9R)-6'-Methoxy-3alpha,8alpha-cinchonan-9-ol
  • (9R)-6'-methoxy-8alpha-cinchonan-9-ol
  • (R)-(-)-quinine
  • (R)-(-)-Quinine, 6-methoxycinchonidine
  • (R)-(6-methoxy-4-quinolyl)-[(2S,4S,5R)-5-vinylquinuclidin-2-yl]methanol
  • (R)-(6-Methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol
  • (R)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methanol
  • 2-Quinuclidinemethanol, alpha-(6-methoxy-4-quinolyl)-5-vinyl-
  • 6'-Methoxycinchonan-9-ol
  • 6'-Methoxycinchonidine
  • 6'-Methoxycinchonine
  • 6-Methoxycinchonine
  • A7V27PHC7A
  • Aflukin
  • Biquinate (*Bisulfate heptathydrate*)
  • CAS-130-95-0
  • CCRIS 5755
  • Chinin
  • Chinine
  • chininum
  • Chininum purum
  • Cinchonan-9-ol, 6'-methoxy-
  • Cinchonan-9-ol, 6'-methoxy-, (8.alpha.,9R)-, sulfate
  • Cinchonan-9-ol, 6'-methoxy-, (8a,9R)-
  • Dentojel (*Bisulfate heptathydrate*)
  • Epitope ID:131786
  • GNF-Pf-506
  • HSDB 2501
  • Hydrochloride, Quinine
  • Quinamm (*2:1 Sulfate salt*), dihydrate
  • Quine (*2:1 Sulfate salt*, dihydrate)
  • Quinidine Sulfate EP Impurity A
  • quinina
  • Quinine
  • Quinine (Standard)
  • quinine bisulphate
  • Quinine, 90%
  • Quinine, Anhydrous
  • Quinine, tannate
  • Quinineanhydrous
  • Quinoline alkaloid
  • Quinsan
  • Quinsan (*2:1 Sulfate salt*), dihydrate
  • Quinson
  • Quinsul
  • Rezquin

Systematic names

  • (5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl)-(6-methoxyquinolin-4-yl)methanol
  • (R)-((4S,5R,7S)-5-ethenyl-1-azabicyclo(2.2.2)octan-7-yl)-(6-methoxyquinolin-4-yl)methanol
  • (R)-[(1S,2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol
  • (R)-[(2S,4S,5R)-1-Aza-5-vinylbicyclo[2.2.2]oct-2-yl](6-methoxyquinolin-4-yl)methanol
  • (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol
  • (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol

Hazard reference values

No reference value for this substance in the sources we hold.

Evidence and how bodies read it

Studies, and the differing conclusions regulators drew from them, are curated by hand rather than machine-read, and none has been written for this substance yet.

Sources for this page

  • ecfr retrieved 2026-09-07

Full licence terms and publisher details on Sources. How this page is built and updated: Method.

Machine-readable:/api/v1/additives/quinine.json