Alpha-tocopherol
18920-62-2 · 2074-53-5 · 59-02-9 · (+)-a-Tocopherol · (+)-alpha-Tocopherol · (2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL · (2R,4'R,8'R)-alpha-Tocopherol · (all rac)-α-Tocopherol · (R)-2,5,7,8-Tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-ol · (R,R,R)-alpha-Tocopherol · 5,7,8-Trimethyltocol · a-D-Tocopherol · a-Vitamin E · Almefrol · alpha Tocopherol · alpha-Tocopherol · alpha-Tocopherol, D- · alpha-Vitamin E · Aquasol E · Covitol F 1000 · d-a-tocopherol · D-alpha tocopherol · D-alpha-Tocopherol · Denamone · DL-Tocopherol · dl-α-Tocopherol · E 307 · Emipherol · Endo E · Eprolin · Eprolin S · Epsilan · Esorb · Etamican · Etavit · Evion · Evitaminum · ido-E · Ilitia · Lan-E · Med-E · Phytogermine · Profecundin · rel-|A-Vitamin E · Spavit E · Syntopherol · Tenox GT 1 · Tocopherol (R,S) · Tocopherol alpha · Tokopharm · Vascuals · Vita E · Vitamin Ea · Vitaplex E · Vitayonon · Viteolin · Viterra E · Waynecomycin · E307 · (2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-ol · (2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-ol · (2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol · (2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol · 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-, (2R)- · Alpha-tocopherol · α-Tocopherols · alfa tokoferol · Alfa tokoferolis · Alfa-tocoferol · ALFA-TOCOFEROLO · Alfa-tocopherol · Alfa-tokoferol · Alfa-tokoferols · ALFA-TOKOFEROOL · Alfatocoferolo · Alfatokoferol · Alfatokoferoli · Alpha-Tocopherol · TOCOFEROL ALFA · α -TOKOFEROL · α-tokoferool · α-τοκοφερόλη · Алфа-токоферолE number E307CAS 59-02-9

Alpha-tocopherol is a form of vitamin E used as an antioxidant in fats, oils and a wide range of other foods.
Where it is and isn’t permitted
| Jurisdiction | Status | Scope and limits | Citation |
|---|---|---|---|
| Australia and New Zealand | Permitted | 2 food categories no numerical limit (good manufacturing practice) Show every food category
| Food Standards Code, Schedule 15, S15—5and 1 further provisionretrieved 2026-10-17 |
| Canada | No listing matchedHealth Canada’s lists name additives without E or INS numbers, so this site matches them by exact name. A substance listed there under a name this site does not recognise has no row here. | ||
| European Union | Permitted, with conditions | 74 food categories highest permitted level 100 mg/l Show every food category
| Regulation (EC) No 1333/2008and 73 further provisionsretrieved 2026-10-18 |
| Great Britain | Permitted, with conditions | 71 food categories highest permitted level 100 mg/kg or mg/l Show every food category
| Assimilated Regulation (EC) No 1333/2008and 70 further provisionsretrieved 2026-10-18 |
| Japan | No listing matchedThis site imports only Japan’s list of designated additives (Appended Table 1 to the Regulations for Enforcement of the Food Sanitation Act), matched by English name. Existing additives, natural flavouring agents and ordinary foods used as additives are permitted outside that list and are not imported, so an empty row does not show that Japan does not permit the substance. | ||
| South Korea | Permitted, with conditions | Designated food additive: Standards and Specifications for Food Additives, Part III, 1. …Designated food additive: Standards and Specifications for Food Additives, Part III, 1. 일반식품첨가물 (general food additives), d-α-토코페롤 (“d-α-Tocopherol Concentrate”, the English the Code prints beside it); the Code marks it as also usable as a nutrient fortifier; 3. 영양강화제 (nutrient fortifiers), d-α-토코페롤; nutrient: 비타민E; the Code marks it as also usable as a general food additive. Main use (주용도) of d-α-토코페롤: 산화방지제. Standard for use (사용기준) of d-α-토코페롤: (1) [to be used under the general standard for use in II. 2. 1), the minimum amount that achieves the technical effect, with no limit set for this additive in particular] “II. 2. 1)의 규정에 따라 사용하여야 한다.” The Korean is the standard as published. There is no official English translation of the current Code (the English version on MFDS’s website is the 2020 edition and has no legal effect); the English in square brackets is this site’s description of what each sentence does, not a translation of the foods or the levels. Compositional specifications (Part IV) are not imported, nor are the general standards in Part II, which apply to every additive. | Standards and Specifications for Food Additives (식품첨가물의 기준 및 규격), MFDS Notification, Part III (Standards for use, by item)retrieved 2026-10-18 |
| United States | Permitted | 21 CFR 184.1890retrieved 2026-10-17 | |
| Codex Alimentarius | Not listedDoes not appear on this jurisdiction’s permitted list. That is not the same as being prohibited. |
How much is permitted
A listing usually limits the quantity as well as the food. Only one of the forms that takes is a figure: quantum satis and good manufacturing practice permit the amount the technological effect requires and no more, which is a limit rather than the absence of one. Figures below are the range across every food category this page is listed in, and categories differ between regulators — see how much is permitted.
| Australia and New Zealand | — | 2 GMP |
|---|---|---|
| European Union | 10 mg/kg – 100 mg/kg | 4 numeric limit, 46 several limits, 1 quantum satis, 23 no quantity stated |
| Great Britain | 10 mg/kg – 100 mg/kg | 4 numeric limit, 1 several limits, 66 quantum satis |
| South Korea | — | 1 no quantity stated |
| United States | — | 1 no quantity stated |
What it is made from
Produced by chemical synthesis or concentrated from vegetable oils.
- Vegan
- Vegetarian
Compare other additives on the dietary indexes.
Allergen labelling
- Annex II exception for soybeans. Natural d-alpha-tocopherol is often from soybean oil. Annex II item 6(b) names natural d-alpha-tocopherol, its acetate and its succinate from soybean sources as exceptions; synthetic forms are not made from soy.
The EU’s list of allergens an ingredients list must emphasise is Regulation (EU) No 1169/2011, Annex II (consolidated text of 1 April 2025). Whether a product must declare one depends on what its additive was actually made from, which the label may not show; see the allergen origin index.
- CAS registry number
- 59-02-9
- InChIKey
- GVJHHUAWPYXKBD-IEOSBIPESA-N
- PubChem
- CID 14985
The two specifications, compared
The European Union sets identity and purity by regulation; JECFA publishes its own through FAO, advisory until a country adopts it. Both documents are below in full. These are the parameters each puts a number on.
| Parameter | European Union | JECFA |
|---|---|---|
| Assay | no less than 96 % | no less than 40 % |
| Sulphated ash | no more than 0.1 % | — |
| Lead | no more than 2 mg/kg | no more than 2 mg/kg |
One parameter differs between the two documents. A difference is not a disagreement about safety: the two are revised on their own cycles, and an assay or a drying loss can be measured against a different preparation of the substance, which is why only the contaminant ceilings are marked. Within the EU the EU's figure is the one that binds.
How the EU defines it
The legal specification an additive must meet to be sold as this E number in the EU — what it is, how it may be made, and the purity it must reach. From Commission Regulation (EU) No 231/2012.
E 307 Alpha-tocopherol
Synonyms: dl-α-Tocopherol; (all rac)-α-Tocopherol
Assay, identification and purity criteria
Description and assay
- Einecs
- 233-466-0
- Chemical name
- DL-5,7,8-Trimethyltocol; DL-2,5,7,8-tetramethyl-2-(4′,8′,12′-trimethyltridecyl)-6-chromanol
- Chemical formula
- C₂₉H₅₀O₂
- Molecular weight
- 430,71
- Assay
- Content not less than 96 %
- Description
- Slightly yellow to amber, nearly odourless, clear, viscous oil which oxidises and darkens on exposure to air or light
Identification
- Solubility
- Insoluble in water, freely soluble in ethanol, miscible in ether
- Spectrophotometry
- In absolute ethanol the maximum absorption is about 292 nm
- Specific rotation
- [α]D ²⁵ 0° ± 0,05° (1 in 10 solution in chloroform)
Purity criteria
- Refractive index
- [n]D ²⁰ 1,503-1,507
- Specific absorption in ethanol
- [image] (292 nm) 71-76 (0,01 g in 200 ml of absolute ethanol)
- Sulphated ash
- Not more than 0,1 %
- Lead
- Not more than 2 mg/kg
How JECFA defines it
The international specification for identity and purity, prepared by the Joint FAO/WHO Expert Committee on Food Additives and published by FAO. It is a different document from any above, written by a different body and revised on its own cycle; it is advisory, and a country adopts it or does not.
INS 307a d-alpha-Tocopherol Concentrate
d-alpha-Tocopherol, concentrate is a form of Vitamin E obtained by the vacuum steam distillation of edible vegetable oil products, comprising a concentrated form of d-alpha-tocopherol. It may contain an edible vegetable oil added to adjust the required amount of total tocopherols, and the content of d-alpha-tocopherol may be adjusted by suitable physical and chemical means.
Synonyms: Vitamin E, RRR-alpha -tocopherol, 5,7,8-trimethyltocol, (+)-alpha-Tocopherol; INS No. 307a (+)-alpha-Tocopherol; 5,7,8-trimethyltocol; RRR-alpha-tocopherol; Vitamin E
Assay, identification and purity criteria
Description and assay
- Specification history
- d- α -TOCOPHEROL, CONCENTRATE Prepared at the 55th JECFA (2000) and published in FNP 52 Add 8 (2000), superseding tentative specifications prepared at the 30th JECFA (1986) and published in FNP 37 (1986) and in FNP 52 (1992). A group ADI of 0.15-2 mg/kg bw for dl- α -tocopherol and d- α -tocopherol, concentrate, singly or in combination, was established at the 30th JECFA (1986).
- Chemical names
- (2R,4’R,8’R)-2,5,7,8-tetramethyl-2-(4’,8’,12’-trimethyltridecyl)-chroman-6-ol
- C.A.S. number
- No. 59-02-9 (Vitamin E)
- Chemical formula
- C29H50O2
- Formula weight
- 430.71
- Assay
- Not less than 40% of total tocopherols, of which not less than 95% consists of d-alpha-tocopherol
- DESCRIPTION
- Brownish red to light yellow, nearly odourless, clear viscous oil, which oxidizes and darkens slowly in air and on exposure to light
- FUNCTIONAL USES
- Antioxidant, nutrient
- METHOD OF ASSAY
- Gas Liquid Chromatographic Method (Volume 4) Reagents and solutions Internal Standard Solution: Transfer about 600 mg of hexadecyl hexadecanoate, accurately weighed, to a 200-ml volumetric flask, dissolve in a solution containing 2 parts of pyridine and 1 part of propionic anhydride, dilute to volume with the solution, and mix. Standard solution Transfer 12-, 25-, 37-, and 50-mg portions of USP Alpha Tocopherol Reference Standard, accurately weighed, to separate 50-ml Erlenmeyer flasks having 19/38 standard-taper ground-glass necks. Pipet 25.0 ml of the Internal Standard Solution into each flask, mix, and reflux for 10 min. under water-cooled condensers. Sample solution Transfer about 60 mg of the sample, accurately weighed, to another 50-ml Erlenmeyer flask, pipet 10.0 ml of the Internal Standard Solution into the flask, mix, and reflux for 10 min. under a water-cooled condenser. Chromatographic System Use a gas chromatograph equipped with a flame-ionization detector and a glass-lined sample-introduction system or on-column injection. Under typical conditions, the instrument contains a 2-m x 4-mm borosilicate glass column packed with 2% to 5% methylpolysiloxane on 80- to 100-mesh acid-base washed siliconized chromatographic diatomaceous earth. The column is maintained isothermally between 240 o and 260 o , the injection port at about 290 o , and the detector block at about 300 o . The flow rate of dry carrier gas is adjusted to obtain a hexadecyl-hexadecanoate peak approximately 18 to 20 min after sample introduction when a 2% stationary phase is used, or 30 to 32 min when a 5% stationary phase is used. (Note: Cure and condition the column as necessary). System Suitability Chromatograph a suitable number of injections of the sample solution, as directed under Calibration, to assure that the resolution factor R, between the major peaks occurring at retention times of approximately 0.50 (delta-tocopherol propionate) and 0.63 (beta- and gamma-tocopheryl propionates), relative of hexadecyl hexadecanoate at 1.00, is not less than 2.5. Calibration Chromatograph successive 2- to 5-μl portions of each standard solution until the relative response factor F, for each is constant (i.e. within a range of approximately 2%) for three consecutive injections. If graphic integration is used, adjust the instrument to obtain at least 70% maximum recorder response for the hexadecyl hexadecanoate peak. Measure the areas under the first (alpha-tocopheryl propionate) and second (hexadecyl hexadecanoate) major peaks, and record the values as As and A1, respectively. Calculate the factor F, for each concentration of (As/A1) x (C1/Cs), in which C1 and Cs are the exact concentrations, in mg per ml, of hexadecyl hexadecanoate and of USP Alpha Tocopherol Reference Standard in the Standard Preparation, respectively. Prepare a relative response factor curve by plotting area of alpha-tocopheryl propionate versus relative response factor. Procedure Inject a suitable portion (2 to 5 μl) of the Assay Preparation into the chromatograph, and record the chromatogram. Measure the areas under the four major peaks occurring at relative retention times of 0.50, 0.63, 0.76, and 1.00, and record the values as A δ , A β + γ , A α and A1, corresponding to delta-tocopherol propionate, beta- and gamma-tocopheryl propionates, alpha-tocopheryl propionate, and hexadecyl hexadecanoate, respectively. Calculate the weight, in mg, of each tocopherol form in the sample by the following formulas. delta-tocopherol = (10C1/F) x (A δ /A1) beta- and gamma-tocopherols = (10C1/F) x (A β + γ /A1) alpha-tocopherol = (10C1/F) x (A α /A1) where F is obtained from the relative response factor curve (see Calibration) for each of the corresponding areas under the delta-, beta- and gamma-, and alpha-tocopheryl propionate peaks produced by the Assay Preparation. (NOTE: The relative response factors for delta-tocopheryl propionate and for beta- and gamma-tocopheryl propionates have been determined empirically to be the same as for alpha-tocopheryl propionate).
Identification
- Solubility (Vol. 4)
- Insoluble in water; soluble in ethanol; miscible with ether
- Chromatography
- The retention time of the major peak in the chromatogram of the sample solution is the same as that of the standard solution, both relative to the internal standard, as obtained in the Assay.
- Colour reaction
- Dissolve about 0.05 g of the sample in 10 ml of absolute ethanol. Add, with swirling, 2 ml of nitric acid and heat at about 75 o for 15 min. A bright red to orange colour develops
Purity criteria
- Specific rotation
- alpha (25, D): Not less than +24 o See description under TESTS
- Acidity
- Dissolve 1 g of the sample in 25 ml of a mixture of equal volumes of ethanol and ether that has been neutralized to phenolphthalein TS with 0.1 N sodium hydroxide, add 0.5 ml of phenolphthalein TS, and titrate with 0.1 N sodium hydroxide until the solution remains faintly pink after shaking for 30 sec. Not more than 1.0 ml of 0.1 N sodium hydroxide is required.
- Lead (Vol. 4)
- Not more than 2 mg/kg Determine using an atomic absorption technique appropriate to the specified level. The selection of sample size and method of sample preparation may be based on the principles of the method described in Volume 4, “Instrumental methods”.
- Test: Specific rotation
- Transfer an accurately weighed sample, equivalent to about 100 mg of total tocopherols, to a separator, and dissolve it in 50 ml of ether. To the separator add 20 ml of a 10% solution of potassium ferricyanide in 0.8% sodium hydroxide solution, and shake for 3 min. Wash the ether solution with four 50-ml portions of water, discard the washings, and dry over anhydrous sodium sulfate. Evaporate the dried ether solution on a water bath under reduced pressure or in an atmosphere of nitrogen until about 7 or 8 ml remain, and then complete the evaporation, removing the last traces of ether without the application of heat. Immediately dissolve the residue in 5 ml of isooctane, and determine the optical rotation. Calculate the specific rotation, using as c the concentration expressed as the number of g of total tocopherols, determined in the Assay, in 100 ml of the solution.
Authorised in other additives, enzymes, flavourings and nutrients
These authorisations are not for use in food. They let this substance be used inside another additive, a food enzyme, a flavouring or a nutrient preparation — often as a carrier — and it reaches food only as part of that product. Annex III to Regulation (EC) No 1333/2008.
| Part | May be used in | Maximum level | Citation |
|---|---|---|---|
| Annex III, Part 2: Food additives other than carriers in food additives | All food additive preparationsAuthorised as a member of Table 1 of Part 6, listed as "Table 1" Note (1): Except enzymes authorised as food additives. | quantum satis | Regulation (EC) No 1333/2008, Annex III, Part 2, via Table 1 of Part 6 |
| Annex III, Part 3: Food additives including carriers in food enzymes | Food enzymesNote (1): Including enzymes authorised as food additives. | In enzyme preparation: quantum satis In final food except beverages: quantum satis In beverages: quantum satis | Regulation (EC) No 1333/2008, Annex III, Part 3 |
| Annex III, Part 4: Food additives including carriers in food flavourings | All flavouringsAuthorised as a member of Table 1 of Part 6, listed as "Table 1" | quantum satis | Regulation (EC) No 1333/2008, Annex III, Part 4, via Table 1 of Part 6 |
| Annex III, Part 5, Section A: Food additives added in nutrients except in nutrients intended to be used in foodstuffs listed in Part E, point 01.10, of Annex II and foodstuffs for infants and young children listed in Part E, point 13.1, of Annex II | All nutrients | quantum satis | Regulation (EC) No 1333/2008, Annex III, Part 5, Section A |
| Annex III, Part 5, Section B: Food additives added in nutrients intended to be used in foodstuffs listed in Part E, point 01.10, of Annex II and foodstuffs for infants and young children listed in Part E, point 13.1, of Annex II | All nutrients (food category: Foods for infants and young children, and foods mentioned in Part E, point 01.10, of Annex II)Listed jointly as "E 306 E 307 E 308 E 309 Tocopherol-rich extract Alpha-tocopherol Gamma-tocopherol Delta-tocopherol" | For uses in nutrient preparations under the condition that the maximum level in foods mentioned in Part E, points 01.10 and 13.1, of Annex II is not exceeded | Regulation (EC) No 1333/2008, Annex III, Part 5, Section B |
Every name it appears under
83 recorded names. A label may use any of them.
E number
- E307
CAS registry number
- 18920-62-2
- 2074-53-5
- 59-02-9
As it appears in regulation
- Alpha-tocopherol
- α-Tocopherols
Other names
- (+)-a-Tocopherol
- (+)-alpha-Tocopherol
- (2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL
- (2R,4'R,8'R)-alpha-Tocopherol
- (all rac)-α-Tocopherol
- (R)-2,5,7,8-Tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-6-ol
- (R,R,R)-alpha-Tocopherol
- 5,7,8-Trimethyltocol
- a-D-Tocopherol
- a-Vitamin E
- Almefrol
- alpha Tocopherol
- alpha-Tocopherol
- alpha-Tocopherol, D-
- alpha-Vitamin E
- Aquasol E
- Covitol F 1000
- d-a-tocopherol
- D-alpha tocopherol
- D-alpha-Tocopherol
- Denamone
- DL-Tocopherol
- dl-α-Tocopherol
- E 307
- Emipherol
- Endo E
- Eprolin
- Eprolin S
- Epsilan
- Esorb
- Etamican
- Etavit
- Evion
- Evitaminum
- ido-E
- Ilitia
- Lan-E
- Med-E
- Phytogermine
- Profecundin
- rel-|A-Vitamin E
- Spavit E
- Syntopherol
- Tenox GT 1
- Tocopherol (R,S)
- Tocopherol alpha
- Tokopharm
- Vascuals
- Vita E
- Vitamin Ea
- Vitaplex E
- Vitayonon
- Viteolin
- Viterra E
- Waynecomycin
Systematic names
- (2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran-6-ol
- (2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-ol
- (2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol
- (2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol
- 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-, (2R)-
The EU re-evaluation programme
Every additive authorised in the EU before 20 January 2009 was put back through EFSA by Commission Regulation (EU) No 257/2010, and this one is named in it. What the Regulation required is below; whether the opinion has since been published is not something this site records.
- To be evaluated by 31 December 2015. Named in Annex II, Part II, point 1 as “Alpha-tocopherol”, among the additives given priority within its class.
Hazard reference values
No reference value for this substance in the sources we hold.
Evidence and how bodies read it
What assessing bodies concluded
Each conclusion is paraphrased in the body's own framing, from the published opinion linked beneath it. Where bodies differ, both stand; this site does not adjudicate between them or add a view of its own.
EFSA 2015
The ANS Panel considered the data too limited to establish an ADI for the tocopherols (E 306–E 309), and found no concern for genotoxicity or carcinogenicity. Taking into account that vitamin E is an essential nutrient and upper intake levels were not generally exceeded, it concluded that tocopherols are not of safety concern at the levels used in food.
Common questions
Assembled from what is above, in the words the questions are usually asked in. Each answer is the same statement the relevant section makes, with the same citations behind it.
- What is E 307?
- E 307 is Alpha-tocopherol. Alpha-tocopherol is a form of vitamin E used as an antioxidant in fats, oils and a wide range of other foods.
- Where is Alpha-tocopherol permitted?
- Of the seven regulators this site reads, Australia and New Zealand, the EU, Great Britain, South Korea and the US permit it. Each permission is for named foods at named levels, not a blanket one; the table on this page gives them with citations.
- Is Alpha-tocopherol vegan?
- Yes. Alpha-tocopherol is not derived from animals, and is suitable for vegetarians. This page says what it is made from and how.
Sources for this page
- anz retrieved 2026-10-17
- eu retrieved 2026-10-18
- gb retrieved 2026-10-18
- kr retrieved 2026-10-18
- ecfr retrieved 2026-10-17
- euspecs retrieved 2026-10-18
- jecfaspecs retrieved 2026-09-23
Full licence terms and publisher details on Sources. How this page is built and updated: Method.
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