Calcium disodium EDTA

E number E385INS 385CAS 62-33-9

Used as a preservative — Codex also lists it as antioxidant, colour retention agent.

Calcium disodium EDTA is a sequestrant that binds trace metals, preventing the discolouration, rancidity and flavour loss they cause. It is used in dressings, canned goods, sauces and soft drinks.

Where it is and isn’t permitted

Status of Calcium disodium EDTA by jurisdiction. Every jurisdiction this site covers is listed, including those where the substance does not appear.
JurisdictionStatusScope and limitsCitation
United StatesFood and Drug AdministrationPermitted, with conditions21 CFR 172.120retrieved 2026-09-07
Codex AlimentariusCodex Alimentarius Commission / JECFAPermitted, with conditions

36 food categories

highest permitted level 1,000 mg/kg

Show every food category
  • 02.2.2 Fat spreads, dairy fat spreads and blended spreads — 100 mg/kg
  • 04.1.2.10 Fermented fruit products — 250 mg/kg
  • 04.1.2.11 Fruit fillings for pastries — 650 mg/kg
  • 04.1.2.2 Dried fruit — 265 mg/kg
  • 04.1.2.3 Fruit in vinegar, oil, or brine — 250 mg/kg
  • 04.1.2.5 — 130 mg/kg
  • 04.1.2.6 Fruit-based spreads (e.g. chutney) excluding products of food category — 100 mg/kg
  • 04.2.2.1 Frozen vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweeds and nuts and seeds — 100 mg/kg
  • 04.2.2.2 Dried vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweeds, and nuts and seeds — 800 mg/kg
  • 04.2.2.3 Vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), and seaweeds in vinegar, oil, brine, or soybean sauce — 250 mg/kg
  • 04.2.2.4 Canned or bottled (pasteurized) or retort pouch vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), and seaweeds — 365 mg/kg
  • 04.2.2.5 Vegetable (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweed, and nut and seed purees and spreads (e.g. peanut butter) — 250 mg/kg
  • 04.2.2.6 Vegetable (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), seaweed, and nut and seed pulps and preparations (e.g. vegetable desserts and sauces, candied vegetables) other than food category 04.2.2.5 — 80 mg/kg
  • 04.2.2.7 Fermented vegetable (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera) and seaweed products, excluding fermented soybean products of food categories 06.8.6, 06.8.7, 12.9.1, — 250 mg/kg
  • 04.2.2.8 Cooked or fried vegetables (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera), and seaweeds — 250 mg/kg
  • 05.1.3 Cocoa-based spreads, incl. fillings — 50 mg/kg
  • 06.5 Cereal and starch based desserts (e.g. rice pudding, tapioca pudding) — 315 mg/kg
  • 08.3.2 Heat-treated processed comminuted meat, poultry, and game products — 35 mg/kg
  • 09.2.1 Frozen fish, fish fillets, and fish products, including molluscs, crustaceans, and echinoderms — 75 mg/kg
  • 09.2.2 Frozen battered fish, fish fillets and fish products, including molluscs, crustaceans, and echinoderms — 75 mg/kg
  • 09.2.4.1 Cooked fish and fish products — 50 mg/kg
  • 09.3.2 Fish and fish products, including molluscs, crustaceans and echinoderms, pickled and/or in brine — 250 mg/kg
  • 09.4 Fully preserved, including canned or fermented fish and fish products, including molluscs, crustaceans, and echinoderms — 340 mg/kg
  • 10.2.3 Dried and/or heat coagulated egg products — 200 mg/kg
  • 11.6 Table-top sweeteners, including those containing high-intensity sweeteners — 1,000 mg/kg
  • 12.2 Herbs, spices, seasonings, and condiments (e.g. seasoning for instant noodles) — 70 mg/kg
  • 12.4 Mustards — 75 mg/kg
  • 12.6.1 Emulsified sauces and dips (e.g. mayonnaise, salad dressing, onion dips) — 100 mg/kg
  • 12.6.2 Non-emulsified sauces (e.g. ketchup, cheese sauce, cream sauce, brown gravy) — 75 mg/kg
  • 12.7 Salads (e.g. macaroni salad, potato salad) and sandwich spreads excluding cocoa-and nut-based spreads of food categories 04.2.2.5 and 05.1.3 — 100 mg/kg
  • 13.6 Food supplements — 150 mg/kg
  • 14.1.4 Water-based flavoured drinks, including "sport," “energy,” or "electrolyte" drinks and particulated drinks — 200 mg/kg
  • 14.1.5 Coffee, coffee substitutes, tea, herbal infusions, and other hot cereal and grain beverages, excluding cocoa — 35 mg/kg
  • 14.2.1 Beer and malt beverages — 25 mg/kg
  • 14.2.6 Distilled spirituous beverages containing more than 15% alcohol — 25 mg/kg
  • 14.2.7 Aromatized alcoholic beverages (e.g. beer, wine and spirituous cooler-type beverages, low-alcoholic refreshers) — 25 mg/kg
CXS 192-1995 Table One, INS 385and 35 further provisionsretrieved 2026-09-07

What it is made from

Synthesised from ethylenediamine and chloroacetic acid, then complexed with calcium and sodium. The calcium form is used in food rather than the disodium form because it does not strip calcium from the body.

  • Vegan
  • Vegetarian
CAS registry number
62-33-9
InChIKey
SHWNNYZBHZIQQV-UHFFFAOYSA-J
PubChem
CID 6093170

Every name it appears under

65 recorded names. A label may use any of them.

E number

  • E0088
  • E385

INS number

  • 385

CAS registry number

  • 23411-34-9
  • 62-33-9

As it appears in regulation

  • Calcium disodium EDTA

Other names

  • (Ethylenedinitrilo)tetraacetic acid calcium disodium salt
  • 25IH6R4SGF
  • Adsorbonac
  • Antallin
  • Antallin; Calcitetracemate disodium; Calcium EDTA; Calcium disodium (ethylenedinitrilo)tetraacetate; Calcium disodium EDTA; Calcium disodium Versenate
  • C10H12CaN2Na2O8
  • Calciate(2-), ((ethylenedinitrilo)tetraacetato)-, disodium
  • Calcium disodium (ethylenedinitrilo)tetraacetate
  • Calcium disodium (ethylenedinitrilo)tetraacetate dihydrate
  • Calcium disodium edetate
  • Calcium disodium edetate hydrate
  • Calcium disodium EDTA
  • Calcium disodium EDTA dihydrate
  • Calcium Disodium EDTA Hydrate
  • Calcium disodium ethylene diamine tetra-acetate (Calcium disodium EDTA)
  • CALCIUM DISODIUM ETHYLENE-DIAMINETETRAACETATE
  • Calcium disodium ethylened iaminetetraacetate hydrate
  • Calcium disodium ethylenediaminetetraacetate
  • Calcium disodium ethylenediaminetetraacetate dihydrate
  • Calcium Edetate Sodium
  • Calcium sodium 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate (1/2/1)
  • calcium sodium edetate
  • Calcium titriplex
  • CAS-62-33-9
  • Detoxamin
  • DISODIUM CALCIUM EDTA
  • DISODIUM((ETHYLENEDINITRILO)TETRAACETATO)CALCIATE(2-)
  • Disodium((ethylenedinitrilo)tetraacetato)calciate(2-) hydrate
  • E 385
  • Edetamine
  • Edetate calcium disodium
  • Edetate calcium disodium anhydrous
  • Edetate calcium disodium anhydrous (USP)
  • EDTA CALCIUM
  • EDTA calcium disodium
  • EDTA calcium disodium salt
  • Edthamil
  • ETHYLENE DIAMINE TETRA ACETATES
  • Ethylene diamine tetraacetic acid, disodium calcium salt
  • Ethylenediaminetetraacetic acid calcium disodium salt
  • Ethylenediaminetetraacetic Acid Disodium Calcium Salt
  • Ethylenediaminetetraaceticacidcalciumdisodiumsalt
  • INS NO.385
  • INS-385
  • Mosatil
  • SHWNNYZBHZIQQV-UHFFFAOYSA-J
  • Sodium calcium edetate
  • Sodium calcium edetate, European Pharmacopoeia (EP) Reference Standard
  • Sormetal
  • Tetazine

Systematic names

  • CALCIATE (2-), ((N,N'-1,2-ETHANEDIYLBIS(N-(CARBOXYMETHYL)GLYCINATO))(4-)-N,N',O,O',ON,ON')-, DISODIUM
  • CALCIATE (2-), ((N,N'-1,2-ETHANEDIYLBIS(N-(CARBOXYMETHYL)GLYCINATO))(4-)-N,N',O,O',ON,ON')-, DISODIUM, (OC-6-21)-
  • CALCIATE(2-), ((N,N'-1,2-ETHANEDIYLBIS(N-((CARBOXY- .KAPPA.O)METHYL)GLYCINATO-.KAPPA.N,.KAPPA.O))(4-))-, DISODIUM, (OC-6-21)-
  • CALCIATE(2-), ((N,N'-1,2-ETHANEDIYLBIS(N-((CARBOXY- .KAPPA.O)METHYL)GLYCINATO-.KAPPA.N,.KAPPA.O))(4-))-, SODIUM (1:2), (OC-6-21)-
  • Calciate(2-), ((N,N'-1,2-ethanediylbis(N-((carboxy-kappaO)methyl)glycinato-kappaN,kappaO))(4-))-, sodium (1:2), (OC-6-21)-
  • calcium disodium 2-((2-(bis(carboxymethyl)amino)ethyl)(carboxymethyl)amino)acetate
  • calcium disodium 2-({2-[bis(carboxylatomethyl)amino]ethyl}(carboxylatomethyl)amino)acetate
  • Calcium;2-[2-[bis(carboxylatomethyl)azaniumyl]ethyl-(carboxylatomethyl)azaniumyl]acetate
  • calcium;disodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate

Hazard reference values

Values set by assessing bodies. A body that has not set a value is not listed here.
TypeValuePopulationAssessed byOpinion
ADI2.5 mg/kg bw/dayconsumersEFSAnot identified in the dataset

Evidence and how bodies read it

Studies, and the differing conclusions regulators drew from them, are curated by hand rather than machine-read, and none has been written for this substance yet.

Sources for this page

  • ecfr retrieved 2026-09-07
  • gsfa retrieved 2026-09-07

Full licence terms and publisher details on Sources. How this page is built and updated: Method.

Machine-readable:/api/v1/additives/calcium-disodium-edta.json