Choline chloride

CAS 67-48-1

Choline chloride is a nutrient added to infant formula and fortified foods. Choline is essential for cell membranes and is now recognised as a nutrient in its own right rather than a B vitamin.

Where it is and isn’t permitted

Status of Choline chloride by jurisdiction. Every jurisdiction this site covers is listed, including those where the substance does not appear.
JurisdictionStatusScope and limitsCitation
United StatesFood and Drug AdministrationPermitted21 CFR 182.8252retrieved 2026-09-07
Codex AlimentariusCodex Alimentarius Commission / JECFANot listedDoes not appear on this jurisdiction’s permitted list. That is not the same as being prohibited.

What it is made from

Produced by chemical synthesis from ethylene oxide, trimethylamine and hydrochloric acid.

  • Vegan
  • Vegetarian
CAS registry number
67-48-1
InChIKey
SGMZJAMFUVOLNK-UHFFFAOYSA-M
PubChem
CID 6209

Every name it appears under

53 recorded names. A label may use any of them.

CAS registry number

  • 67-48-1

As it appears in regulation

  • Choline chloride

Other names

  • (.beta.-Hydroxyethyl)trimethylammonium chloride
  • (2-H2-Hydroxyethyl)trimethylammonium chloride
  • (2-Hydroxyethyl)trimethylammonium chloride
  • (2-hydroxyethyl)trimethylazanium chloride
  • (beta-Hydroxyethyl)trimethylammonium chloride
  • 2-(trimethylamino)ethan-1-ol, chloride
  • 2-Hydroxy-N,N,N,-trimethylethanaminium chloride
  • 2-Hydroxy-N,N,N-trimethylethan-1-aminium chloride
  • 2-Hydroxy-N,N,N-trimethylethanaminium chloride
  • 2-Hydroxy-N,N,N-trimethylethanaminium chloride (1:1)
  • 2-hydroxyethyl(trimethyl)ammonium;chloride
  • 2-Hydroxyethyl(trimethyl)azanium;chloride
  • Acetylcholine Chloride EP Impurity A; Carbachol EP Impurity A
  • Acetylcholine chloride EP Impurity A;<br>Carbachol EP Impurity A
  • Ammonium, (2-hydroxyethyl)trimethyl-, chloride
  • Bilineurin chloride
  • Biocolina
  • Biocoline
  • CAS-67-48-1
  • CCRIS 3716
  • Chloride de choline
  • Chloride, Choline
  • Chlorure de choline
  • Choline (chloride) (Standard)
  • CHOLINE (CL)
  • Choline chlorhydrate
  • Choline chloride
  • Choline chloride - 75% water solution
  • Choline chloride - 99%
  • Choline hydrochloride
  • Cholini chloridum
  • cholinii chloridum
  • cholinium chloratum
  • Cholinium chloride
  • Cloruro de colina
  • Colina cloruro
  • Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride
  • Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride (1:1)
  • FEMA NO. 4500
  • Hepacholine
  • HMS500F09
  • Hormocline
  • HSDB 984
  • Lipotril
  • Luridin chloride
  • Neocolina
  • Paresan
  • Trimethyl(2-hydroxyethyl)ammonium chloride
  • WLN: Q2K1&1&1 &Q &G

Systematic names

  • (2-Hydroxyethyl)trimethylammonium chloride;Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride;Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride (1:1)
  • 2-Hydroxyethyl(trimethyl)azanium chloride

Hazard reference values

No reference value for this substance in the sources we hold.

Evidence and how bodies read it

Studies, and the differing conclusions regulators drew from them, are curated by hand rather than machine-read, and none has been written for this substance yet.

Sources for this page

  • ecfr retrieved 2026-09-07

Full licence terms and publisher details on Sources. How this page is built and updated: Method.

Machine-readable:/api/v1/additives/choline-chloride.json