Cyclamate and its derivatives

Cyclamate is an intense sweetener about thirty to fifty times as sweet as sugar. The United States prohibited it in food in 1969; it remains permitted in the European Union, Canada and many other jurisdictions, which makes it one of the clearest cases of regulators reaching different conclusions.

Where it is and isn’t permitted

Status of Cyclamate and its derivatives by jurisdiction. Every jurisdiction this site covers is listed, including those where the substance does not appear.
JurisdictionStatusScope and limitsCitation
United StatesFood and Drug AdministrationProhibited21 CFR 189.135retrieved 2026-09-07
Codex AlimentariusCodex Alimentarius Commission / JECFANot listedDoes not appear on this jurisdiction’s permitted list. That is not the same as being prohibited.

What it is made from

Made by sulfonating cyclohexylamine, a petroleum-derived intermediate, and isolating the sodium or calcium salt. No animal material is involved.

  • Vegan
  • Vegetarian

Every name it appears under

1 recorded name. A label may use any of them.

As it appears in regulation

  • Cyclamate and its derivatives

Hazard reference values

No reference value for this substance in the sources we hold.

Evidence and how bodies read it

How different bodies read the evidence

Positions are paraphrased in each body's own framing. Where they differ, both stand; this site does not adjudicate between them.

  1. FDA 1969

    Withdrew cyclamate from food use after a study reported bladder tumours in rats given a cyclamate and saccharin mixture, and has not reinstated it despite later petitions.

    Action taken: Prohibited from use in human food

    Source document

Sources for this page

  • ecfr retrieved 2026-09-07

Full licence terms and publisher details on Sources. How this page is built and updated: Method.

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