Diethylene glycol monoethyl ether

CAS 111-90-0

Chemical structure of Diethylene glycol monoethyl ether, from PubChem compound 8146
Structure from PubChem CID 8146 (National Library of Medicine, public domain). A depiction of one compound: where a listing covers a family, or a substance has no single structure, this page shows none.

A carrier solvent for flavourings. JECFA records that its main use is in citrus flavourings and as a replacement for ethanol where alcohol is not acceptable.

Where it is and isn’t permitted

Status of Diethylene glycol monoethyl ether by jurisdiction. Every jurisdiction this site covers is listed, including those where the substance does not appear.
JurisdictionStatusScope and limitsCitation
Australia and New ZealandFood Standards Australia New ZealandNo listed food uses foundThis site has not matched this substance to any food use on this jurisdiction’s list of authorised food additives. A food additive may be used only in foods that list names. Flavourings, enzymes, processing aids and added nutrients are regulated separately and do not appear on it.
CanadaHealth CanadaNo listing matchedHealth Canada’s lists name additives without E or INS numbers, so this site matches them by exact name. A substance listed there under a name this site does not recognise has no row here.
European UnionEuropean Commission / EFSANo listed food uses foundThis site has not matched this substance to any food use on this jurisdiction’s list of authorised food additives. A food additive may be used only in foods that list names. Flavourings, enzymes, processing aids and added nutrients are regulated separately and do not appear on it.
Great BritainFood Standards Agency / Food Standards ScotlandNo listed food uses foundThis site has not matched this substance to any food use on this jurisdiction’s list of authorised food additives. A food additive may be used only in foods that list names. Flavourings, enzymes, processing aids and added nutrients are regulated separately and do not appear on it.
JapanConsumer Affairs AgencyNo listing matchedThis site imports only Japan’s list of designated additives (Appended Table 1 to the Regulations for Enforcement of the Food Sanitation Act), matched by English name. Existing additives, natural flavouring agents and ordinary foods used as additives are permitted outside that list and are not imported, so an empty row does not show that Japan does not permit the substance.
South KoreaMinistry of Food and Drug SafetyNo listing matchedThis site imports Part III of South Korea’s Standards and Specifications for Food Additives, matched by CAS number, then INS number, then exact name. Mixed preparations and sanitisers are not imported, and an entry whose identifiers disagreed with a page’s is held for review, so an empty row does not show that South Korea does not permit the substance.
United StatesFood and Drug AdministrationNot listedDoes not appear on this jurisdiction’s permitted list. That is not the same as being prohibited.
Codex AlimentariusCodex Alimentarius Commission / JECFANot listedDoes not appear on this jurisdiction’s permitted list. That is not the same as being prohibited.

What it is made from

Made by reacting ethylene oxide with ethanol.

  • Vegan
  • Vegetarian

Compare other additives on the dietary indexes.

CAS registry number
111-90-0
InChIKey
XXJWXESWEXIICW-UHFFFAOYSA-N
PubChem
CID 8146

How JECFA defines it

The international specification for identity and purity, prepared by the Joint FAO/WHO Expert Committee on Food Additives and published by FAO. It is a different document from any above, written by a different body and revised on its own cycle; it is advisory, and a country adopts it or does not.

Diethylene Glycol Monoethyl Ether

Synonyms: Ethyl ether of diethylene glycol, ethyldigol, ethylenediglycol Ethyl ether of diethylene glycol; Ethyldigol; Ethylenediglycol

Assay, identification and purity criteria

Description and assay

Specification history
Prepared at the 39th JECFA (1992), published in FNP 52 Add 1 (1992) superseding specifications prepared at the 25th JECFA (1981), published in FNP 19 (1981). Metals and arsenic specifications revised at the 63rd JECFA (2004). No ADI was allocated at the 44th JECFA (1995)
Chemical names
2-(2-Ethoxy)-ethoxyethanol
C.A.S. number
111-90-0
Chemical formula
C 6 H 14 O 3
Formula weight
134.18
DESCRIPTION
Clear, colourless hygroscopic liquid having a mild characteristic odour
FUNCTIONAL USES
Carrier solvent for flavouring (main use will be in citrus flavouring and as a replacer of ethanol in Islamic countries)

Identification

Solubility (Vol. 4)
Miscible with water (shows no opalescence) and ethanol
Specific gravity (Vol. 4)
0.989 - 0.995
Refractive index (Vol. 4)
n (20, D): 1.425 - 1.430

Purity criteria

Distillation range (Vol. 4)
195 o - 205 o
Water (Vol. 4)
Not more than 0.1% (Karl Fischer Method)
Acidity
Not more than 0.01% (as acetic acid) To 60 g of the sample add a few drops of phenolphthalein TS, and titrate with 0.1 N ethanolic potassium hydroxide to a pink end-point which persists for at least 15 sec. Not more than 1 ml is required.
Ethanediol
Not more than 0.3% See description under TESTS
1,4-Dioxane (Vol. 4)
Not more than 10 mg/kg
Lead (Vol. 4)
Not more than 2 mg/kg Determine using an atomic absorption technique appropriate to the specified level. The selection of sample size and method of sample preparation may be based on the principles of the method described in Volume 4, “Instrumental Methods.”
Test: Ethanediol
Mix about 2 g of the sample, accurately weighed, with 100 ml of water, add 25 ml of potassium periodate solution (3.5 g/l), swirl, and allow to stand in the dark for 30 min. Add 20 ml of potassium iodide TS and 25 ml of 2 N sulfuric acid, and titrate the liberated iodine with 0.1 N sodium thiosulfate TS, adding starch TS when the brown iodine colour is nearly discharged. Titrate to the disappearance of the blue colour. Perform a residual blank titration. Calculate the ethanediol content by the formula: where V 1 = volume (ml) of sodium thiosulfate TS (0.1 N), used in blank titration V 2 = volume (ml) of sodium thiosulfate TS (0.1 N), used in sample titration M = weight (g) of sample taken

FAO JECFA Monograph 1 (2006)

Every name it appears under

63 recorded names. A label may use any of them.

CAS registry number

  • 111-90-0
  • 149818-01-9

Other names

  • (Ethoxyethoxy)ethanol
  • 1-Hydroxy-3,6-dioxaoctane
  • 2(2-Ethoxyethoxy)ethanol
  • 2-(.beta.-Ethoxyethoxy)ethanol
  • 2-(2-ETHOXY) ETHANOL
  • 2-(2-ethoxy-ethoxy)-ethanol
  • 2-(2-Ethoxyethoxy)-ethanol
  • 2-(2-ethoxyethoxy)ethan-1-ol
  • 2-(2-Ethoxyethoxy)ethanol
  • 2-(2ethoxyethoxy)ethanol
  • 2-(beta-Ethoxyethoxy)ethanol
  • 2-(Ethoxyethoxy)ethanol
  • 3,6-Dioxa-1-octanol
  • 3,6-Dioxa-1-oktanol
  • 3,6-Dioxaoctan-1-ol
  • Aethyldiaethylenglycol
  • BRN 1736441
  • CARBITOL
  • Carbitol cellosolve
  • Carbitol solvent
  • CAS-111-90-0
  • DEGEE
  • DEGMEE
  • Diethoxol
  • Diethylene glycol ethyl ether
  • Diethylene glycol monoethyl ether
  • Diethylene glycol monoethyl ether (NF)
  • Diethylene glycol monoethyl ether; 2-(2-Ethoxyethoxy)ethanol
  • diethylene glycol-monoethyl ether
  • Diethyleneglycol monoethyl ether
  • diethyleneglycol monoethylether
  • diethyleneglycolmonoethylether
  • Diglycol monoethyl ether
  • Dioxitol
  • Dowanol 17
  • Dowanol DE
  • Eastman DE
  • Ektasolve DE
  • Ethanol, 2,2'-oxybis-, monoethyl ether
  • Ethanol, 2-(2-ethoxyethoxy)-
  • Ethoxy diglycol
  • Ethoxydiglycol
  • Ethyl carbitol
  • Ethyl Di-Icinol
  • Ethyl diethylene glycol
  • Ethyl digol
  • Ethyl ether of diethylene glycol
  • ethylcarbitol
  • Ethyldigol
  • Ethylene diglycol monoethyl ether
  • Ethylenediglycol
  • HSDB 51
  • Karbitol
  • Losungsmittel apv
  • Monoethyl ether of diethylene glycol
  • O-Ethyldigol
  • PEG-3EO
  • Solvolsol
  • Transcutol
  • Transcutol P
  • WLN: Q2O2O2

Hazard reference values

No reference value for this substance in the sources we hold.

Evidence and how bodies read it

Studies, and the differing conclusions regulators drew from them, are curated rather than machine-read, and none has been written for this substance yet.

Common questions

Assembled from what is above, in the words the questions are usually asked in. Each answer is the same statement the relevant section makes, with the same citations behind it.

What is Diethylene glycol monoethyl ether?
A carrier solvent for flavourings. JECFA records that its main use is in citrus flavourings and as a replacement for ethanol where alcohol is not acceptable.
Is Diethylene glycol monoethyl ether vegan?
Yes. Diethylene glycol monoethyl ether is not derived from animals, and is suitable for vegetarians. This page says what it is made from and how.

Sources for this page

  • jecfaspecs retrieved 2026-09-23

Full licence terms and publisher details on Sources. How this page is built and updated: Method.

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