Dipotassium 5'-guanylate

INS 628

Used as a flavour enhancer.

Dipotassium guanylate is a savoury flavour enhancer, the potassium salt of guanylic acid, used where added sodium is unwanted.

Where it is and isn’t permitted

Status of Dipotassium 5'-guanylate by jurisdiction. Every jurisdiction this site covers is listed, including those where the substance does not appear.
JurisdictionStatusScope and limitsCitation
United StatesFood and Drug AdministrationNot listedDoes not appear on this jurisdiction’s permitted list. That is not the same as being prohibited.
Codex AlimentariusCodex Alimentarius Commission / JECFAPermitted, with conditions

1 food category

no numerical limit (good manufacturing practice)

CXS 192-1995 Table Three, INS 628and 1 further provisionretrieved 2026-09-07

What it is made from

Made by neutralising guanylic acid, produced by fermentation or from yeast RNA, with potassium.

  • Vegan status depends on the source
  • Vegetarian status depends on the source
  • May raise a halal question
  • May raise a kosher question

This is not an omission. What this additive is made from is not fixed — depending on the manufacturer it may be plant, animal or microbial in origin, nobody is required to say which, and the same product can change source between production runs. Ask the manufacturer if it matters to you; a label cannot answer it.

InChIKey
BCQFRUIIFOQGFI-LGVAUZIVSA-L
PubChem
CID 135565913

Every name it appears under

16 recorded names. A label may use any of them.

E number

  • E628

INS number

  • 628

CAS registry number

  • 3254-39-5

Other names

  • 5'-Guanylic acid, dipotassium salt
  • 5'-GUANYLIC ACID, POTASSIUM SALT (1:2)
  • DIPOTASSIUM 5'-GUANYLATE
  • Dipotassium 5'-O-phosphonatoguanosine
  • DIPOTASSIUM GUANOSINE-5'-MONOPHOSPHATE
  • Dipotassium guanylate
  • GUANOSINE 5'-MONOPHOSPHATE DIPOTASSIUM SALT
  • INS NO.628
  • INS-628
  • POTASSIUM 5'-GUANYLATE
  • potassium guanylate
  • Potassium guanylatePotassium 5'-guanylate

Systematic names

  • dipotassium;[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate

Hazard reference values

No reference value for this substance in the sources we hold.

Evidence and how bodies read it

Studies, and the differing conclusions regulators drew from them, are curated by hand rather than machine-read, and none has been written for this substance yet.

Sources for this page

  • gsfa retrieved 2026-09-07

Full licence terms and publisher details on Sources. How this page is built and updated: Method.

Machine-readable:/api/v1/additives/dipotassium-5-guanylate.json