Disodium guanylate

E number E627INS 627CAS 5550-12-9

Used as a flavour enhancer.

Disodium guanylate is a flavour enhancer used alongside MSG and inosinate, and is the reason a small amount of MSG can carry a whole seasoning.

Where it is and isn’t permitted

Status of Disodium guanylate by jurisdiction. Every jurisdiction this site covers is listed, including those where the substance does not appear.
JurisdictionStatusScope and limitsCitation
United StatesFood and Drug AdministrationPermitted, with conditions21 CFR 172.530retrieved 2026-09-07
Codex AlimentariusCodex Alimentarius Commission / JECFAPermitted, with conditions

10 food categories

no numerical limit (good manufacturing practice)

Show every food category
  • 04.2.2.7 Fermented vegetable (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera) and seaweed products, excluding fermented soybean products of food categories 06.8.6, 06.8.7, 12.9.1, — GMP
  • 06.4.2 Dried pastas and noodles and like products — GMP
  • 08.1 Fresh meat, poultry, and game — GMP
  • 09.2.1 Frozen fish, fish fillets, and fish products, including molluscs, crustaceans, and echinoderms — GMP
  • 09.2.2 Frozen battered fish, fish fillets and fish products, including molluscs, crustaceans, and echinoderms — GMP
  • 09.2.3 Frozen minced and creamed fish products, including molluscs, crustaceans, and echinoderms — GMP
  • 09.2.4 Cooked and/or fried fish and fish products, including molluscs, crustaceans, and echinoderms — GMP
  • 09.2.5 Smoked, dried, fermented, and/or salted fish and fish products, including molluscs, crustaceans, and echinoderms — GMP
  • 12.1.2 Salt substitutes — GMP
  • 14.1.5 Coffee, coffee substitutes, tea, herbal infusions, and other hot cereal and grain beverages, excluding cocoa — GMP
CXS 192-1995 Table Three, INS 627and 10 further provisionsretrieved 2026-09-07

What it is made from

Produced by bacterial fermentation, though extraction from yeast or fish is also possible. The source is not usually declared, so a vegetarian cannot be certain from a label alone.

  • Vegan status depends on the source
  • Vegetarian status depends on the source
  • May raise a halal question
  • May raise a kosher question

This is not an omission. What this additive is made from is not fixed — depending on the manufacturer it may be plant, animal or microbial in origin, nobody is required to say which, and the same product can change source between production runs. Ask the manufacturer if it matters to you; a label cannot answer it.

CAS registry number
5550-12-9
InChIKey
PVBRXXAAPNGWGE-LGVAUZIVSA-L
PubChem
CID 135414246

Every name it appears under

57 recorded names. A label may use any of them.

E number

  • E627

INS number

  • 627

CAS registry number

  • 111036-20-5
  • 13474-02-7
  • 550-12-9
  • 5550-12-9

As it appears in regulation

  • Disodium guanylate

Other names

  • 5'-GMP 2Na
  • 5'-Gmp disodium salt
  • 5'-Guanylic acid disodium salt
  • 5'-Guanylic acid, sodium salt (1:2)
  • 5-Guanylic Acid .X Sodium Salt
  • 5-Guanylic acid disodium salt
  • ANHYDROUS DISODIUM GUANYLATE
  • CCRIS 6561
  • disodium 5'--guanylate
  • Disodium 5'-gmp
  • DISODIUM 5'-GUANYLATE
  • Disodium 5'-guanylate (VAN)
  • Disodium 5'-guanylate; 5'-GMP 2Na; 5'-Guanylic acid disodium salt
  • disodium 5'-O-phosphonatoguanosine
  • Disodium GMP
  • Disodium guanos
  • Disodium guanosine 5'-monophosphate
  • Disodium guanosine-5'-monophosphate
  • Disodium guanylate
  • DISODIUM GUANYLATE (MART.)
  • DISODIUM GUANYLATE (USP-RS)
  • E 627
  • FEMA No. 3668
  • GMP
  • GMP disodium salt
  • GMP sodium salt
  • GMP.Na2
  • Guanosine 5 inverted exclamation marka-monophosphate disodium salt hydrate
  • Guanosine 5'-monophosphate disodium salt
  • Guanosine 5'-phosphate disodium salt
  • Guanosine 5'MP, disodium salt
  • Guanosine 5-Monophosphate Disodium Salt
  • Guanosine-5'-monophosphate disodium salt
  • Guanosine-5'phosphate disodium salt
  • GUANYLIC ACID DISODIUM
  • Guanylic acid sodium salt
  • INS NO.627
  • INS-627
  • PVBRXXAAPNGWGE-LGVAUZIVSA-L
  • Sodium 5'-guanylate
  • Sodium GMP
  • Sodium guanosine 5'-monophosphate
  • Sodium guanylate
  • Sodium guanylateSodium 5'-guanylate

Systematic names

  • [(3S,2R,4R,5R)-5-(2-amino-6-oxohydropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methy l dihydrogen phosphate, sodium salt, sodium salt
  • disodium [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
  • disodium [(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
  • disodium;[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
  • sodium ((2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate
  • Sodium ((2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate

Hazard reference values

No reference value for this substance in the sources we hold.

Evidence and how bodies read it

Studies, and the differing conclusions regulators drew from them, are curated by hand rather than machine-read, and none has been written for this substance yet.

Sources for this page

  • ecfr retrieved 2026-09-07
  • gsfa retrieved 2026-09-07

Full licence terms and publisher details on Sources. How this page is built and updated: Method.

Machine-readable:/api/v1/additives/disodium-guanylate.json