Dulcin

Dulcin was an early artificial sweetener, discovered in 1884 and roughly two hundred times as sweet as sugar. The FDA prohibited it in 1950 following toxicity findings in animals, and it has no current food use.

Where it is and isn’t permitted

Status of Dulcin by jurisdiction. Every jurisdiction this site covers is listed, including those where the substance does not appear.
JurisdictionStatusScope and limitsCitation
United StatesFood and Drug AdministrationProhibited21 CFR 189.145retrieved 2026-09-07
Codex AlimentariusCodex Alimentarius Commission / JECFANot listedDoes not appear on this jurisdiction’s permitted list. That is not the same as being prohibited.

What it is made from

Synthesised from p-phenetidine, an aromatic amine derived from petroleum feedstocks. It has been of historical interest only since its prohibition.

  • Vegan
  • Vegetarian
InChIKey
GGLIEWRLXDLBBF-UHFFFAOYSA-N
PubChem
CID 9013

Every name it appears under

43 recorded names. A label may use any of them.

E number

  • E1171

CAS registry number

  • 150-69-6

As it appears in regulation

  • Dulcin

Other names

  • (4-ethoxyphenyl)-urea
  • (4-ethoxyphenyl)urea
  • (P-ETHOXYPHENYL)UREA
  • 1-(4-Ethoxyphenyl)urea
  • 4-13-00-01154 (Beilstein Handbook Reference)
  • 4-Ethoxy-phenylurea
  • 4-ETHOXYPHENYLUREA
  • 4-Ureidophenetole
  • amino-N-(4-ethoxyphenyl)amide
  • BRN 2096445
  • CAS-150-69-6
  • CCRIS 5913
  • Dulcin
  • Dulcin (>90%)
  • Dulcin?
  • Dulcine
  • Dulein
  • HMS548E07
  • HSDB 8048
  • N-(4-Ethoxyphenyl)urea
  • p-Aethoxyphenylharnstoff
  • p-Ethoxyfenylmo
  • p-Ethoxyfenylmocovina
  • p-Ethoxyphenylurea
  • p-Phenethylurea
  • p-Phenetolcarbamid
  • p-Phenetolcarbamide
  • p-Phenetolecarbamide
  • p-Phenetylurea
  • p-Ureidophenetole
  • Phenethylcarbamid
  • Phenetolcarbamide
  • Sucrol
  • Suesstoff
  • Urea, (4-ethoxyphenyl)-
  • Urea, (4-ethoxyphenyl)- (9CI)
  • Urea, (p-ethoxyphenyl)-
  • Urea, N-(4-ethoxyphenyl)-
  • Valzin
  • WLN: ZVMR DO2

Hazard reference values

No reference value for this substance in the sources we hold.

Evidence and how bodies read it

Studies, and the differing conclusions regulators drew from them, are curated by hand rather than machine-read, and none has been written for this substance yet.

Sources for this page

  • ecfr retrieved 2026-09-07

Full licence terms and publisher details on Sources. How this page is built and updated: Method.

Machine-readable:/api/v1/additives/dulcin.json