Glucono delta-lactone

INS 575CAS 90-80-2

Used as an acidity regulator — Codex also lists it as raising agent, sequestrant.

Glucono-delta-lactone is an acid that releases slowly as it dissolves, which makes it the coagulant for silken tofu and the acidifier in cured sausages and some baking powders. The delay is the point of it.

Where it is and isn’t permitted

Status of Glucono delta-lactone by jurisdiction. Every jurisdiction this site covers is listed, including those where the substance does not appear.
JurisdictionStatusScope and limitsCitation
United StatesFood and Drug AdministrationPermitted21 CFR 184.1318retrieved 2026-09-07
Codex AlimentariusCodex Alimentarius Commission / JECFAPermitted, with conditions

4 food categories

no numerical limit (good manufacturing practice)

Show every food category
  • 01.2.1.2 Fermented milks (plain), heat-treated after fermentation — GMP
  • 01.6.6 Whey protein cheese — GMP
  • 06.4.1 Fresh pastas and noodles and like products — GMP
  • 13.2 Complementary foods for infants and young children — GMP
CXS 192-1995 Table Three, INS 575and 4 further provisionsretrieved 2026-09-07

What it is made from

Produced by fermenting glucose to gluconic acid and then drying it into the lactone ring form, which reverts to the acid on contact with water.

  • Vegan
  • Vegetarian
CAS registry number
90-80-2
InChIKey
PHOQVHQSTUBQQK-SQOUGZDYSA-N
PubChem
CID 7027

Every name it appears under

62 recorded names. A label may use any of them.

INS number

  • 575

CAS registry number

  • 1335-57-5
  • 4253-68-3
  • 90-80-2

As it appears in regulation

  • Glucono delta-lactone

Other names

  • (3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-one
  • (3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-one
  • (3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-one
  • .delta.-D-Gluconolactone
  • .delta.-Gluconolactone
  • 1,5-D-Gluconolactone
  • 1,5-Gluconolactone
  • beta-Glucono-1,5-lactone
  • Canagliflozin Impurity H1
  • CAS-90-80-2
  • D-(+)-Gluconic acid d-lactone
  • D-(+)-Gluconic acid delta-lactone
  • D-(+)-Gluconic acid |A-lactone
  • d-(+)-Glucono-1,5-lactone
  • D-Aldonolactone
  • D-delta-Gluconolactone
  • d-Gluconic acid .delta.-lactone
  • D-Gluconic acid 1,5-lactone
  • d-gluconic acid d-lactone
  • D-Gluconic acid delta-lactone
  • D-Gluconic acid lactone
  • D-Gluconic acid-1,5-lactone
  • D-Gluconic acid-delta-lactone
  • D-Gluconic delta-lactone
  • D-glucono-1,5-lactone
  • D-glucono-delta-lactone
  • D-threo-Aldono-1,5-lactone
  • delta gluconolactone
  • delta-Aldonolactone
  • delta-D-Gluconolactone
  • delta-gluconolactone
  • Deltagluconolactone
  • Fujiglucon
  • Glucarolactone
  • Glucolactone
  • Gluconate, lactone
  • Gluconic Acid Anhydride
  • Gluconic Acid delta-Lactone
  • Gluconic acid lactone
  • Gluconic acid lactone (6CI)
  • Gluconic acid, delta-lactone, D-
  • Gluconic delta-lactone
  • Gluconic lactone
  • Glucono .delta.-lactone
  • Glucono delta lactone
  • Glucono delta-lactone
  • glucono-1,5-lactone
  • glucono-delta-lactone
  • gluconolactone
  • Gluconolactone (USP)
  • HSDB 488
  • INS NO.575
  • INS-575
  • LGC
  • Lysactone
  • Riken lactone
  • WQ29KQ9POT

Hazard reference values

No reference value for this substance in the sources we hold.

Evidence and how bodies read it

Studies, and the differing conclusions regulators drew from them, are curated by hand rather than machine-read, and none has been written for this substance yet.

Sources for this page

  • ecfr retrieved 2026-09-07
  • gsfa retrieved 2026-09-07

Full licence terms and publisher details on Sources. How this page is built and updated: Method.

Machine-readable:/api/v1/additives/glucono-delta-lactone.json