L-Lysine monohydrochloride
10098-89-2 · 28826-16-6 · 657-27-2 · (2S)-2,6-bis(azanyl)hexanoic acid hydrochloride · (2S)-2,6-diaminohexanoic acid hydrochloride · (2S)-2,6-Diaminohexanoic acid monohydrochloride · (S)-2,6-Diaminohexanoic acid hydrochloride · (S)-2,6-Diaminohexanoic acid hydrochloride(1:x) · (S)-2,6-Diaminohexanoic acid monohydrochloride · (S)-2,6-Diaminohexanoic acid xhydrochloride · Darvyl · Enisyl · ENISYL-F · H-Lys-OH.HCl · H-Lys-OH.HCl L-Lysine monohydrochloride (from non-animal source) · JNJ23Q2COM · l(+)-lysine monohy-drochloride · l(+)-lysine monohydrochloride · L-(+)-Lysine Monohydrochloride · L-alpha,epsilondiaminocaproic acid monohydrochloride · L-Gen · L-lysine HCl · L-Lysine hydrochloride · L-Lysine hydrochloride (JP17) · L-Lysine hydrochloride (Standard) · L-Lysine hydrochloride (VAN) · L-Lysine hydrochloride, >=98%, natural, FG · L-Lysine hydrochloride, United States Pharmacopeia (USP) Reference Standard · L-Lysine Monohydrochloride · L-Lysine monohydrochloride, BioUltra, >=99.5% (AT) · L-Lysine monohydrochloride, Cell Culture Reagent (H-L-Lys-OH.HCl) · L-Lysine monohydrochloride, certified reference material, TraceCERT(R) · L-Lysine monohydrochloride, p.a., 98.5% · L-Lysine monohydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material · L-Lysine monohydrochloride, reagent grade, >=98% (HPLC) · L-Lysine monohydrochloride, SAJ special grade, >=99.0% · L-Lysine monohydrocholoride · L-Lysine, hydrochloride (1:1) · L-Lysine, hydrochloride (1:?) · L-Lysine--hydrogen chloride (1/1) · L-Lysine-Hydrochloride · Lyamine · Lysine HCl · Lysine hcl, l- · lysine hydrochloride · Lysine Hydrochloride (L-Lysine Hydrochloride) · Lysine hydrochloride (USP) · Lysine hydrochloride (VAN) · Lysine hydrochloride CRS · Lysine hydrochloride, European Pharmacopoeia (EP) Reference Standard · Lysine monohydrochloride · Lysine, l-, monohydrochloride · Lysine, monohydrochloride, L- · Lysion · nBu-PLys(100)*HCl · Poly-L-lysine hydrochloride - MW 3300Da · Trulysine · VIRALYS · L-Lysine monohydrochloride, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%
The hydrochloride salt of the essential amino acid lysine, added to foods as a nutrient rather than for a technological effect.
Where it is and isn’t permitted
| Jurisdiction | Status | Scope and limits | Citation |
|---|---|---|---|
| Australia and New Zealand | No listed food uses foundThis site has not matched this substance to any food use on this jurisdiction’s list of authorised food additives. A food additive may be used only in foods that list names. Flavourings, enzymes, processing aids and added nutrients are regulated separately and do not appear on it. | ||
| Canada | Permitted, with conditions | highest permitted level 8,000 mg/kg In: Processed snack foods based on dried potato dough; Processed snack foods based on wheat flour dough. Purpose: To inhibit acrylamide formation. Limit: 8,000 ppm, calculated as L-lysine. Amendment notices: NOM/ADM-0140. | Health Canada, List of Permitted Food Additives with Other Purposes of Use (List 8), item L.6retrieved 2026-10-17 |
| European Union | No listed food uses foundThis site has not matched this substance to any food use on this jurisdiction’s list of authorised food additives. A food additive may be used only in foods that list names. Flavourings, enzymes, processing aids and added nutrients are regulated separately and do not appear on it. | ||
| Great Britain | No listed food uses foundThis site has not matched this substance to any food use on this jurisdiction’s list of authorised food additives. A food additive may be used only in foods that list names. Flavourings, enzymes, processing aids and added nutrients are regulated separately and do not appear on it. | ||
| Japan | Permitted, with conditions | Designated additive: Appended Table 1, item 441, Ｌ―リシン塩酸塩（別名Ｌ―リジン塩酸塩） (“L-Lysine Monohydrochloride” in the unofficial English translation). …Designated additive: Appended Table 1, item 441, Ｌ―リシン塩酸塩（別名Ｌ―リジン塩酸塩） (“L-Lysine Monohydrochloride” in the unofficial English translation). Standards for use — Specifications and Standards for Foods, Food Additives, etc. (MHW Notification No. 370 of 1959), Part II (Food Additives), F (Standards for use): The Notification sets no standard for use (使用基準) for this additive, so it is not restricted there to particular foods or amounts. Compositional specifications for this additive, in the same Notification, are not imported and are not shown here; nor are the general rules in F 添加物一般, which apply to every additive. | Regulations for Enforcement of the Food Sanitation Act (MHW Ordinance No. 23 of 1948), Appended Table 1retrieved 2026-10-18 |
| South Korea | Permitted, with conditions | Designated food additive: Standards and Specifications for Food Additives, Part III, 3. …Designated food additive: Standards and Specifications for Food Additives, Part III, 3. 영양강화제 (nutrient fortifiers), L-라이신염산염; nutrient: 아미노산. Standard for use (사용기준) of L-라이신염산염: (1) [to be used under the general standard for use in II. 2. 1), the minimum amount that achieves the technical effect, with no limit set for this additive in particular] “II. 2. 1)의 규정에 따라 사용하여야 한다.” The Korean is the standard as published. There is no official English translation of the current Code (the English version on MFDS’s website is the 2020 edition and has no legal effect); the English in square brackets is this site’s description of what each sentence does, not a translation of the foods or the levels. Compositional specifications (Part IV) are not imported, nor are the general standards in Part II, which apply to every additive. | Standards and Specifications for Food Additives (식품첨가물의 기준 및 규격), MFDS Notification, Part III (Standards for use, by item)retrieved 2026-10-18 |
| United States | Permitted, with conditions | Named in 21 CFR 172.320 among the amino acids that may be added to foods as nutrients: paragraph (a)(13) lists L-lysine, paragraph (a) allows the listed amino acids "as the hydroch …Named in 21 CFR 172.320 among the amino acids that may be added to foods as nutrients: paragraph (a)(13) lists L-lysine, paragraph (a) allows the listed amino acids "as the hydrochloride, sodium, or potassium salts", and paragraph (b)(1)(xvii) names L-Lysine Monohydrochloride in the specifications. The section lists the amino acids as a group, which this site holds as the page amino-acids; read it for the conditions and specifications. | 21 CFR 172.320retrieved 2026-10-18 |
| Codex Alimentarius | Not listedDoes not appear on this jurisdiction’s permitted list. That is not the same as being prohibited. |
How much is permitted
A listing usually limits the quantity as well as the food. Only one of the forms that takes is a figure: quantum satis and good manufacturing practice permit the amount the technological effect requires and no more, which is a limit rather than the absence of one. Figures below are the range across every food category this page is listed in, and categories differ between regulators — see how much is permitted.
| Canada | 8,000 mg/kg | 1 numeric limit |
|---|---|---|
| Japan | — | 1 no quantity stated |
| South Korea | — | 1 no quantity stated |
| United States | — | 1 no quantity stated |
GRAS notices to the FDA
A GRAS notice is a company’s conclusion that a substance is generally recognised as safe for the use it describes. FDA’s letter responds to that conclusion, for that notifier and that use. It is not a listing in 21 CFR, and it is not counted as a US permission above. The substance and use are as FDA’s inventory words them; this site matched the notice to this page by exact name.
GRN No. 414 · L-lysine monohydrochloride · The Procter & Gamble Company
Intended use: To reduce the formation of acrylamide in fabricated snack products at use levels up to 1.5% (1.2% as lysine)
FDA’s response (2012-11-20): FDA has no questions
What it is made from
Made by bacterial fermentation of a carbohydrate source and isolated as the hydrochloride.
- Vegan
- Vegetarian
Compare other additives on the dietary indexes.
- InChIKey
- BVHLGVCQOALMSV-JEDNCBNOSA-N
- PubChem
- CID 69568
Every name it appears under
59 recorded names. A label may use any of them.
CAS registry number
- 10098-89-2
- 28826-16-6
- 657-27-2
Other names
- (2S)-2,6-bis(azanyl)hexanoic acid hydrochloride
- (2S)-2,6-diaminohexanoic acid hydrochloride
- (2S)-2,6-Diaminohexanoic acid monohydrochloride
- (S)-2,6-Diaminohexanoic acid hydrochloride
- (S)-2,6-Diaminohexanoic acid hydrochloride(1:x)
- (S)-2,6-Diaminohexanoic acid monohydrochloride
- (S)-2,6-Diaminohexanoic acid xhydrochloride
- Darvyl
- Enisyl
- ENISYL-F
- H-Lys-OH.HCl
- H-Lys-OH.HCl L-Lysine monohydrochloride (from non-animal source)
- JNJ23Q2COM
- l(+)-lysine monohy-drochloride
- l(+)-lysine monohydrochloride
- L-(+)-Lysine Monohydrochloride
- L-alpha,epsilondiaminocaproic acid monohydrochloride
- L-Gen
- L-lysine HCl
- L-Lysine hydrochloride
- L-Lysine hydrochloride (JP17)
- L-Lysine hydrochloride (Standard)
- L-Lysine hydrochloride (VAN)
- L-Lysine hydrochloride, >=98%, natural, FG
- L-Lysine hydrochloride, United States Pharmacopeia (USP) Reference Standard
- L-Lysine Monohydrochloride
- L-Lysine monohydrochloride, BioUltra, >=99.5% (AT)
- L-Lysine monohydrochloride, Cell Culture Reagent (H-L-Lys-OH.HCl)
- L-Lysine monohydrochloride, certified reference material, TraceCERT(R)
- L-Lysine monohydrochloride, p.a., 98.5%
- L-Lysine monohydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
- L-Lysine monohydrochloride, reagent grade, >=98% (HPLC)
- L-Lysine monohydrochloride, SAJ special grade, >=99.0%
- L-Lysine monohydrocholoride
- L-Lysine, hydrochloride (1:1)
- L-Lysine, hydrochloride (1:?)
- L-Lysine--hydrogen chloride (1/1)
- L-Lysine-Hydrochloride
- Lyamine
- Lysine HCl
- Lysine hcl, l-
- lysine hydrochloride
- Lysine Hydrochloride (L-Lysine Hydrochloride)
- Lysine hydrochloride (USP)
- Lysine hydrochloride (VAN)
- Lysine hydrochloride CRS
- Lysine hydrochloride, European Pharmacopoeia (EP) Reference Standard
- Lysine monohydrochloride
- Lysine, l-, monohydrochloride
- Lysine, monohydrochloride, L-
- Lysion
- nBu-PLys(100)*HCl
- Poly-L-lysine hydrochloride - MW 3300Da
- Trulysine
- VIRALYS
Systematic names
- L-Lysine monohydrochloride, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%
Hazard reference values
No reference value for this substance in the sources we hold.
Evidence and how bodies read it
Studies, and the differing conclusions regulators drew from them, are curated rather than machine-read, and none has been written for this substance yet.
Common questions
Assembled from what is above, in the words the questions are usually asked in. Each answer is the same statement the relevant section makes, with the same citations behind it.
- What is L-Lysine monohydrochloride?
- The hydrochloride salt of the essential amino acid lysine, added to foods as a nutrient rather than for a technological effect.
- Is L-Lysine monohydrochloride banned in Europe?
- No. L-Lysine monohydrochloride does not appear on the EU's list of authorised food additives, which is not the same as being banned: the EU permits an additive only where it has authorised it, and usually the reason for an absence is that no one applied. The EU has made no finding against this substance. It does mean it may not be used as a food additive in the EU today.
- Where is L-Lysine monohydrochloride permitted?
- Of the seven regulators this site reads, Canada, Japan, South Korea and the US permit it. Each permission is for named foods at named levels, not a blanket one; the table on this page gives them with citations.
- Is L-Lysine monohydrochloride vegan?
- Yes. L-Lysine monohydrochloride is not derived from animals, and is suitable for vegetarians. This page says what it is made from and how.
Sources for this page
- ca retrieved 2026-10-17
- jp retrieved 2026-10-18
- kr retrieved 2026-10-18
- us-listings retrieved 2026-10-18
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