Magnesium gluconate

INS 580

Used as an acidity regulator — Codex also lists it as firming agent, flavour, enhancer.

Magnesium gluconate is a magnesium source in fortified foods and supplements, and an acidity regulator.

Where it is and isn’t permitted

Status of Magnesium gluconate by jurisdiction. Every jurisdiction this site covers is listed, including those where the substance does not appear.
JurisdictionStatusScope and limitsCitation
United StatesFood and Drug AdministrationNot listedDoes not appear on this jurisdiction’s permitted list. That is not the same as being prohibited.
Codex AlimentariusCodex Alimentarius Commission / JECFAPermitted

no numerical limit (good manufacturing practice)

CXS 192-1995 Table Three, INS 580retrieved 2026-09-07

What it is made from

Made by reacting a magnesium source with fermentation-derived gluconic acid.

  • Vegan
  • Vegetarian
InChIKey
HJWFTNWQKDPLAS-SYAJEJNSSA-L
PubChem
CID 71587201

Every name it appears under

14 recorded names. A label may use any of them.

CAS registry number

  • 59625-89-7

Other names

  • D-Gluconic acid, magnesium salt (2:1), hydrate
  • E-580(magnesium gluconate)
  • HJWFTNWQKDPLAS-SYAJEJNSSA-L
  • Ins no.580(magnesium gluconate)
  • Ins-580(magnesium gluconate)
  • Magnesium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate dihydrate
  • Magnesium (as gluconate)
  • Magnesium D-gluconate (1:2) dihydrate
  • Magnesium D-gluconate (1:2) hydrate
  • Magnesium gluconate
  • Magnesium gluconate,dihydrate
  • Magnesium gluconicum
  • T42NAD2KHC

Hazard reference values

No reference value for this substance in the sources we hold.

Evidence and how bodies read it

Studies, and the differing conclusions regulators drew from them, are curated by hand rather than machine-read, and none has been written for this substance yet.

Sources for this page

  • gsfa retrieved 2026-09-07

Full licence terms and publisher details on Sources. How this page is built and updated: Method.

Machine-readable:/api/v1/additives/magnesium-gluconate.json