Morpholine
110-91-8 · 138048-80-3 · 1-Oxa-4-azacyclohexane · 1-Oxa-4-azacyclohexane; Tetrahydro-2H-1,4-oxazine · 2H-1,4-Oxazine, tetrahydro- · 4-27-00-00015 (Beilstein Handbook Reference) · 4H-1, tetrahydro- · 4H-1,4-Oxazine, tetrahydro- · 8B2ZCK305O · BASF 238 · BRN 0102549 · CAS-110-91-8 · Caswell No. 584 · CCRIS 2482 · Diethylene imidoxide · Diethylene oximide · Diethyleneimide oxide · Diethylenimide oxide · Drewamine · EPA Pesticide Chemical Code 054701 · HSDB 102 · InChI=1/C4H9NO/c1-3-6-4-2-5-1/h5H,1-4H · Molsidomine EP Impurity E · morphline · morpho line · morpholin · Morpholine · Morpholine (BASF) · Morpholine on Rasta Resin · Morpholine purified by distillation from glass · Morpholine(Discontinued,See C4X-20707) · Morpholine, ACS reagent, >=99.0% · Morpholine, analytical standard · Morpholine, p.a., ACS reagent, 99.0% · MORPHOLINE, PRACT · Morpholine, purified by redistillation, >=99.5% · Morpholine, ReagentPlus(R), >=99% · MORPHOLINE,REAG · morpholine- · Morpholine; Molsidomine Imp. E (EP); Molsidomine Impurity E · p-Isoxazine, tetrahydro- · Polymer bonded morpholine · Tetrahydro-1,4-isoxazine · Tetrahydro-1,4-oxazine · Tetrahydro-2H-1,4-oxazine · Tetrahydro-4H-1,4-Oxazine · Tetrahydro-4H-1-4-oxazine · Tetrahydro-p-isoxazine · Tetrahydro-p-oxazine · Tetryhydro-2H-1,4-oxazine · WLN: T6M DOTJ · morpholine · ScavengePore(TM) phenethyl morpholine, macroporous, 40-70 mesh, extent of labeling: 0.7-1.5 mmol/g loading · StratoSpheres(TM) PL-MPH resin, 50-100 mesh, extent of labeling: 3.0-4.0 mmol/g loading, 1 % cross-linked · MorpholineCAS 110-91-8
Morpholine is a component of the wax coatings applied to fresh fruit, acting as the agent that lets the wax emulsify in water.
Where it is and isn’t permitted
| Jurisdiction | Status | Scope and limits | Citation |
|---|---|---|---|
| Australia and New Zealand | No listed food uses foundThis site has not matched this substance to any food use on this jurisdiction’s list of authorised food additives. A food additive may be used only in foods that list names. Flavourings, enzymes, processing aids and added nutrients are regulated separately and do not appear on it. | ||
| Canada | No listing matchedHealth Canada’s lists name additives without E or INS numbers, so this site matches them by exact name. A substance listed there under a name this site does not recognise has no row here. | ||
| European Union | No listed food uses foundThis site has not matched this substance to any food use on this jurisdiction’s list of authorised food additives. A food additive may be used only in foods that list names. Flavourings, enzymes, processing aids and added nutrients are regulated separately and do not appear on it. | ||
| Great Britain | No listed food uses foundThis site has not matched this substance to any food use on this jurisdiction’s list of authorised food additives. A food additive may be used only in foods that list names. Flavourings, enzymes, processing aids and added nutrients are regulated separately and do not appear on it. | ||
| Japan | No listing matchedThis site imports only Japan’s list of designated additives (Appended Table 1 to the Regulations for Enforcement of the Food Sanitation Act), matched by English name. Existing additives, natural flavouring agents and ordinary foods used as additives are permitted outside that list and are not imported, so an empty row does not show that Japan does not permit the substance. | ||
| South Korea | No listing matchedThis site imports Part III of South Korea’s Standards and Specifications for Food Additives, matched by CAS number, then INS number, then exact name. Mixed preparations and sanitisers are not imported, and an entry whose identifiers disagreed with a page’s is held for review, so an empty row does not show that South Korea does not permit the substance. | ||
| United States | Permitted, with conditions | 21 CFR 172.235retrieved 2026-10-17 | |
| Codex Alimentarius | Not listedDoes not appear on this jurisdiction’s permitted list. That is not the same as being prohibited. |
How much is permitted
A listing usually limits the quantity as well as the food. Only one of the forms that takes is a figure: quantum satis and good manufacturing practice permit the amount the technological effect requires and no more, which is a limit rather than the absence of one. Figures below are the range across every food category this page is listed in, and categories differ between regulators — see how much is permitted.
| United States | — | 1 no quantity stated |
|---|
No regulator sets a figure for Morpholine. That is not an absence of control: where the listing says quantum satis or good manufacturing practice, the quantity is limited to what the effect requires.
What it is made from
Produced by chemical synthesis from diethylene glycol and ammonia.
- Vegan
- Vegetarian
Compare other additives on the dietary indexes.
- CAS registry number
- 110-91-8
- InChIKey
- YNAVUWVOSKDBBP-UHFFFAOYSA-N
- PubChem
- CID 8083
Every name it appears under
55 recorded names. A label may use any of them.
CAS registry number
- 110-91-8
- 138048-80-3
As it appears in regulation
- Morpholine
Other names
- 1-Oxa-4-azacyclohexane
- 1-Oxa-4-azacyclohexane; Tetrahydro-2H-1,4-oxazine
- 2H-1,4-Oxazine, tetrahydro-
- 4-27-00-00015 (Beilstein Handbook Reference)
- 4H-1, tetrahydro-
- 4H-1,4-Oxazine, tetrahydro-
- 8B2ZCK305O
- BASF 238
- BRN 0102549
- CAS-110-91-8
- Caswell No. 584
- CCRIS 2482
- Diethylene imidoxide
- Diethylene oximide
- Diethyleneimide oxide
- Diethylenimide oxide
- Drewamine
- EPA Pesticide Chemical Code 054701
- HSDB 102
- InChI=1/C4H9NO/c1-3-6-4-2-5-1/h5H,1-4H
- Molsidomine EP Impurity E
- morphline
- morpho line
- morpholin
- Morpholine
- Morpholine (BASF)
- Morpholine on Rasta Resin
- Morpholine purified by distillation from glass
- Morpholine(Discontinued,See C4X-20707)
- Morpholine, ACS reagent, >=99.0%
- Morpholine, analytical standard
- Morpholine, p.a., ACS reagent, 99.0%
- MORPHOLINE, PRACT
- Morpholine, purified by redistillation, >=99.5%
- Morpholine, ReagentPlus(R), >=99%
- MORPHOLINE,REAG
- morpholine-
- Morpholine; Molsidomine Imp. E (EP); Molsidomine Impurity E
- p-Isoxazine, tetrahydro-
- Polymer bonded morpholine
- Tetrahydro-1,4-isoxazine
- Tetrahydro-1,4-oxazine
- Tetrahydro-2H-1,4-oxazine
- Tetrahydro-4H-1,4-Oxazine
- Tetrahydro-4H-1-4-oxazine
- Tetrahydro-p-isoxazine
- Tetrahydro-p-oxazine
- Tetryhydro-2H-1,4-oxazine
- WLN: T6M DOTJ
Systematic names
- morpholine
- ScavengePore(TM) phenethyl morpholine, macroporous, 40-70 mesh, extent of labeling: 0.7-1.5 mmol/g loading
- StratoSpheres(TM) PL-MPH resin, 50-100 mesh, extent of labeling: 3.0-4.0 mmol/g loading, 1 % cross-linked
Hazard reference values
| Type | Value | Population | Assessed by | Opinion |
|---|---|---|---|---|
| ADI | not allocated | consumers | EFSA | 2023 |
Evidence and how bodies read it
Studies, and the differing conclusions regulators drew from them, are curated rather than machine-read, and none has been written for this substance yet.
Common questions
Assembled from what is above, in the words the questions are usually asked in. Each answer is the same statement the relevant section makes, with the same citations behind it.
- What is Morpholine?
- Morpholine is a component of the wax coatings applied to fresh fruit, acting as the agent that lets the wax emulsify in water.
- Is Morpholine banned in Europe?
- No. Morpholine does not appear on the EU's list of authorised food additives, which is not the same as being banned: the EU permits an additive only where it has authorised it, and usually the reason for an absence is that no one applied. The EU has made no finding against this substance. It does mean it may not be used as a food additive in the EU today.
- Where is Morpholine permitted?
- Of the seven regulators this site reads, the US permits it. Each permission is for named foods at named levels, not a blanket one; the table on this page gives them with citations.
- Is Morpholine vegan?
- Yes. Morpholine is not derived from animals, and is suitable for vegetarians. This page says what it is made from and how.
Sources for this page
- ecfr retrieved 2026-10-17
Full licence terms and publisher details on Sources. How this page is built and updated: Method.
Machine-readable: a JSON record of this additive is given on request —how to ask for access.
Follow changes to Morpholine:Atom feed — regulatory events, and any change the weekly refresh detects in its provisions.