Thiodipropionic acid

INS 388

Used as an antioxidant.

Thiodipropionic acid is an antioxidant used to protect fats and oils from rancidity.

Where it is and isn’t permitted

Status of Thiodipropionic acid by jurisdiction. Every jurisdiction this site covers is listed, including those where the substance does not appear.
JurisdictionStatusScope and limitsCitation
United StatesFood and Drug AdministrationPermitted21 CFR 182.3109retrieved 2026-09-07
Codex AlimentariusCodex Alimentarius Commission / JECFAPermitted, with conditions

6 food categories

highest permitted level 1,000 mg/kg

Show every food category
  • 02.1.2 Vegetable oils and fats — 200 mg/kg
  • 02.1.3 Lard, tallow, fish oil, and other animal fats — 200 mg/kg
  • 02.2.2 Fat spreads, dairy fat spreads and blended spreads — 200 mg/kg
  • 09.2.2 Frozen battered fish, fish fillets and fish products, including molluscs, crustaceans, and echinoderms — 200 mg/kg
  • 14.1.4 Water-based flavoured drinks, including "sport," “energy,” or "electrolyte" drinks and particulated drinks — 1,000 mg/kg
  • 15.0 Ready-to-eat savouries — 200 mg/kg
CXS 192-1995 Table One, INS 388and 5 further provisionsretrieved 2026-09-07

What it is made from

Produced by chemical synthesis from acrylic acid and hydrogen sulfide.

  • Vegan
  • Vegetarian
InChIKey
ODJQKYXPKWQWNK-UHFFFAOYSA-N
PubChem
CID 8096

Every name it appears under

54 recorded names. A label may use any of them.

E number

  • E388

INS number

  • 388

CAS registry number

  • 111-17-1

As it appears in regulation

  • Thiodipropionic acid

Other names

  • .beta.,.beta.'-Thiodipropionic acid
  • 3,3 inverted exclamation mark -Thiodipropionic Acid
  • 3,3 inverted exclamation mark(R)-Thiodipropionic acid
  • 3,3 inverted exclamation marka-Thiodipropionic acid
  • 3,3'-Sulfanediyldipropanoic acid
  • 3,3'-Thi
  • 3,3'-Thiobis(propanoic acid)
  • 3,3'-Thiobis-propanoic acid
  • 3,3'-Thiobispropanoic acid
  • 3,3'-Thiodi(propionic acid)
  • 3,3'-Thiodi-Propionic acid
  • 3,3'-Thiodipropanoic acid
  • 3,3'-Thiodipropionic acid
  • 3,3'-Thiodipropionic acid, 8CI
  • 3,3'-Thiodipropionic acid, 97%
  • 3,3'-thiodipropionic acid, 99%
  • 3,3-thiodipropionic acid
  • 3,3-Thiodipropionicacid
  • 3,3\'-Thiodipropionic acid
  • 3-(2-carboxyethylsulanyl)propanoic acid
  • 3-(2-carboxyethylsulfanyl)propanoic acid
  • 3-(2-carboxyethylthio)propanoic acid
  • 3-[(2-carboxyethyl)sulfanyl]propanoic acid
  • 3BBK323ED8
  • 4-Thiaheptanedioic acid
  • 4-Thiaheptanedioio acid
  • Bis(2-carboxyethyl) sulfide
  • CAS-111-17-1
  • CCRIS 3288
  • Diethyl sulfide 2,2'-dicarboxylic acid
  • Diethyl sulfide b,b'-dicarboxylic acid
  • HSDB 858
  • InChI=1/C6H10O4S/c7-5(8)1-3-11-4-2-6(9)10/h1-4H2,(H,7,8)(H,9,10
  • INS NO.388
  • INS-388
  • Kyselina 3,3-thiodipropionova
  • Kyselina beta,beta'-thiodipropionova
  • Propanoic acid, 3,3'-thiobis-
  • Propanoic acid,3'-thiobis-
  • Propionic acid, 3,3'-thiodi-
  • Propionic acid,3'-thiodi-
  • Sulfide, bis(2-carboxyethyl)
  • TDPA
  • Thiahydracrylic acid
  • Thiobispropanoic acid
  • Thiodihydracrylic acid
  • THIODIPROPIONATES
  • THIODIPROPIONIC ACID
  • Tyox A
  • WLN: QV2S2VQ

Hazard reference values

No reference value for this substance in the sources we hold.

Evidence and how bodies read it

Studies, and the differing conclusions regulators drew from them, are curated by hand rather than machine-read, and none has been written for this substance yet.

Sources for this page

  • ecfr retrieved 2026-09-07
  • gsfa retrieved 2026-09-07

Full licence terms and publisher details on Sources. How this page is built and updated: Method.

Machine-readable:/api/v1/additives/thiodipropionic-acid.json