Cyclodextrin, beta-

E number E459INS 459CAS 7585-39-9

Used as a thickener — Codex also lists it as carrier, stabilizer.

Beta-cyclodextrin is a ring-shaped sugar with a hollow centre, used to trap and protect flavours, to mask bitterness, and to remove cholesterol from dairy products.

Where it is and isn’t permitted

Status of Cyclodextrin, beta- by jurisdiction. Every jurisdiction this site covers is listed, including those where the substance does not appear.
JurisdictionStatusScope and limitsCitation
United StatesFood and Drug AdministrationNot listedDoes not appear on this jurisdiction’s permitted list. That is not the same as being prohibited.
Codex AlimentariusCodex Alimentarius Commission / JECFAPermitted, with conditions

8 food categories

highest permitted level 20,000 mg/kg

Show every food category
  • 01.1.4 Flavoured Fluid Milk Drinks — 5 mg/kg
  • 01.2.1.1 Fermented milks (plain), not heat-treated after fermentation — 5 mg/kg
  • 01.2.1.2 Fermented milks (plain), heat-treated after fermentation — 5 mg/kg
  • 01.7 Dairy-based desserts (e.g. pudding, fruit or flavoured yoghurt) — 5 mg/kg
  • 05.3 Chewing gum — 20,000 mg/kg
  • 06.4.3 Pre-cooked pastas and noodles and like products — 1,000 mg/kg
  • 14.1.4 Water-based flavoured drinks, including "sport," “energy,” or "electrolyte" drinks and particulated drinks — 500 mg/kg
  • 15.1 Snacks - potato, cereal, flour or starch based (from roots and tubers, pulses and legumes) — 500 mg/kg
CXS 192-1995 Table One, INS 459and 7 further provisionsretrieved 2026-09-07

What it is made from

Produced by treating starch with cyclodextrin glycosyltransferase, an enzyme that closes chains of seven glucose units into a ring. The ring's interior is water-repelling, which is what lets it hold a guest molecule.

  • Vegan
  • Vegetarian
CAS registry number
7585-39-9
InChIKey
WHGYBXFWUBPSRW-FOUAGVGXSA-N
PubChem
CID 444041

Every name it appears under

63 recorded names. A label may use any of them.

E number

  • E459

INS number

  • 459

CAS registry number

  • 37331-89-8
  • 7585-39-9

Other names

  • -Cyclodextrin(Discontinued,See C4X-25742)
  • .beta.-Cyclodextrin
  • 1dmb
  • 2zyn
  • ALFADEX IMPURITY A [EP IMPURITY]
  • b-Cyclodextrin
  • BETA BYCLODEXTRIN
  • Beta cyclodextrin
  • beta-CD
  • beta-cyclo-dextrin
  • beta-Cycloamylose
  • Beta-cyclodextrin
  • beta-Cyclodextrin, >=97%
  • beta-Cyclodextrin, produced by Wacker Chemie AG, Burghausen, Germany
  • beta-cyclodextrine
  • beta-Cyclodextrins
  • beta-Cycloheptaamylose
  • beta-Dextrin
  • Beta-schardinger dextrin
  • Betacd
  • betacyclodextrin
  • Betadex
  • Betadex (NF/INN)
  • Betadex CRS
  • Betadex, European Pharmacopoeia (EP) Reference Standard
  • Betadex;Alfadex EP Impurity A
  • betadexum
  • CAVAMAX W7
  • CCRIS 651
  • cyclo-epta-amylose
  • Cyclodextrin B
  • CYCLODEXTRIN, BETA-
  • Cycloheptaamylose
  • Cycloheptaglucan
  • Cycloheptaglucosan
  • CYCLOHEPTAKIS-(1->4)-(.ALPHA.-D-GLUCOPYRANOSYL)
  • Cycloheptapentylose
  • Cyclomaltoheptaose
  • Dextrin, beta-cyclo
  • E 459
  • heptakis(hydroxymethyl)[?]tetradecol
  • INS NO.459
  • INS-459
  • JV039JZZ3A
  • Kleptose
  • Kleptose B
  • Maltodecaose DP10
  • Oristar bcd
  • Rhodocap N
  • Ringdex B
  • Ringdex BL
  • Ringdex-b
  • Schardinger A-Dextrin
  • Schardinger beta-dextrin
  • ss-Cyclodextrin
  • SULFOBUTYLBETADEX SODIUM IMPURITY A [EP IMPURITY]
  • yena-Cyclodextrin

Systematic names

  • (1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31S,33R,35R,36R,37R,38R,39R,40R,41R,42R,43R,44R,45R,46R,47R,48R,49R)-5,10,15,20,25,30,35-heptakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.2~3,6~.
  • Betadex; Cycloheptakis-(1?4)-(a-d-glucopyranosyl) (cyclomaltoheptaose); Cycloheptakis-(1?4)-(a-d-glucopyranosyl) ss-cyclodextrin

Hazard reference values

Values set by assessing bodies. A body that has not set a value is not listed here.
TypeValuePopulationAssessed byOpinion
ADI5 mg/kg bw/dayconsumersEFSA ANS2016

Evidence and how bodies read it

Studies, and the differing conclusions regulators drew from them, are curated by hand rather than machine-read, and none has been written for this substance yet.

Sources for this page

  • gsfa retrieved 2026-09-07

Full licence terms and publisher details on Sources. How this page is built and updated: Method.

Machine-readable:/api/v1/additives/cyclodextrin-beta.json