Cyclodextrin, gamma-

INS 458

Used as a thickener — Codex also lists it as stabilizer.

Gamma-cyclodextrin is the eight-unit ring, with the largest cavity of the three and the highest solubility. It is used to carry and stabilise flavours and fat-soluble vitamins.

Where it is and isn’t permitted

Status of Cyclodextrin, gamma- by jurisdiction. Every jurisdiction this site covers is listed, including those where the substance does not appear.
JurisdictionStatusScope and limitsCitation
United StatesFood and Drug AdministrationNot listedDoes not appear on this jurisdiction’s permitted list. That is not the same as being prohibited.
Codex AlimentariusCodex Alimentarius Commission / JECFAPermitted

no numerical limit (good manufacturing practice)

CXS 192-1995 Table Three, INS 458retrieved 2026-09-07

What it is made from

Produced enzymatically from starch, forming a closed ring of eight glucose units.

  • Vegan
  • Vegetarian
InChIKey
GDSRMADSINPKSL-HSEONFRVSA-N
PubChem
CID 5287407

Every name it appears under

37 recorded names. A label may use any of them.

CAS registry number

  • 17465-86-0

Other names

  • .gamma.-Cyclodextrin
  • ALFADEX IMPURITY B [EP IMPURITY]
  • Betadex EP Impurity B;Alfadex EP Impurity B
  • Betadex EP Impurity B
  • Cavamax w8
  • Cyclodextrin, gamma-
  • cyclomalto-octaose
  • Cyclomaltooctaose
  • Cyclooctaamylose
  • CYCLOOCTAKIS-(1->4)-(.ALPHA.-D-GLUCOPYRANOSYL)
  • Cyclooctapentylose
  • Dexy Pearl gamma-100
  • g-cyclodextrin
  • gamma cyclodextrin
  • Gamma Cyclodextrin, United States Pharmacopeia (USP) Reference Standard
  • gamma-CD
  • gamma-Cyclodextrin
  • gamma-Cyclodextrin, >=98%
  • gamma-Cyclodextrin, powder, BioReagent, suitable for cell culture, >=98%
  • gamma-Cyclodextrin, produced by Wacker Chemie AG, Burghausen, Germany, >=90.0% cyclodextrin basis (HPLC)
  • gamma-Cyclodextrin, produced by Wacker Chemie AG, Burghausen, Germany, >=98% (on dry basis)
  • gamma-Cyclodextrin, purum, >=98.0% (HPLC)
  • gamma-Dextrin
  • Gammacyclodextrin
  • Gammacyclodextrin CRS
  • Gammadex [EP monograph]
  • Ins no.458
  • Ins-458
  • KZJ0BYZ5VA
  • Ringdex C
  • Schardinger ?-Dextrin
  • Sugammadex Impurity 48
  • |A-?Cyclodextrin

Systematic names

  • cyclooctakis-(1 inverted exclamation marku4)-(|A-D-glucopyranosyl) (cyclomaltooctaose or |A-cyclodextrin)
  • cyclooctakis-(1 inverted exclamation marku4)-(|A-D-glucopyranosyl) (cyclomaltooctaose or |A-cyclodextrin); Cyclomaltooctaose, Schardinger |A-Dextrin, gamma-Cyclodextrin, Cyclooctaamylose
  • gamma-Cyclodextrin, Produced by Wacker Chemie AG, Burghausen, Germany, Life Science, 98.0-102.0% cyclodextrin basis

Hazard reference values

No reference value for this substance in the sources we hold.

Evidence and how bodies read it

Studies, and the differing conclusions regulators drew from them, are curated by hand rather than machine-read, and none has been written for this substance yet.

Sources for this page

  • gsfa retrieved 2026-09-07

Full licence terms and publisher details on Sources. How this page is built and updated: Method.

Machine-readable:/api/v1/additives/cyclodextrin-gamma.json