Disodium inosinate

E number E631INS 631CAS 4691-65-0

Used as a flavour enhancer.

Disodium inosinate is a flavour enhancer used with MSG, which it multiplies rather than merely adds to: the pair together give far more umami than either alone. It is in most savoury snack seasonings.

Where it is and isn’t permitted

Status of Disodium inosinate by jurisdiction. Every jurisdiction this site covers is listed, including those where the substance does not appear.
JurisdictionStatusScope and limitsCitation
United StatesFood and Drug AdministrationPermitted, with conditions21 CFR 172.535retrieved 2026-09-07
Codex AlimentariusCodex Alimentarius Commission / JECFAPermitted, with conditions

10 food categories

no numerical limit (good manufacturing practice)

Show every food category
  • 04.2.2.7 Fermented vegetable (including mushrooms and fungi, roots and tubers, pulses and legumes, and aloe vera) and seaweed products, excluding fermented soybean products of food categories 06.8.6, 06.8.7, 12.9.1, — GMP
  • 06.4.2 Dried pastas and noodles and like products — GMP
  • 08.1 Fresh meat, poultry, and game — GMP
  • 09.2.1 Frozen fish, fish fillets, and fish products, including molluscs, crustaceans, and echinoderms — GMP
  • 09.2.2 Frozen battered fish, fish fillets and fish products, including molluscs, crustaceans, and echinoderms — GMP
  • 09.2.3 Frozen minced and creamed fish products, including molluscs, crustaceans, and echinoderms — GMP
  • 09.2.4 Cooked and/or fried fish and fish products, including molluscs, crustaceans, and echinoderms — GMP
  • 09.2.5 Smoked, dried, fermented, and/or salted fish and fish products, including molluscs, crustaceans, and echinoderms — GMP
  • 12.1.2 Salt substitutes — GMP
  • 14.1.5 Coffee, coffee substitutes, tea, herbal infusions, and other hot cereal and grain beverages, excluding cocoa — GMP
CXS 192-1995 Table Three, INS 631and 10 further provisionsretrieved 2026-09-07

What it is made from

Produced by bacterial fermentation of a carbohydrate feedstock, though it can also be extracted from meat or fish, in which case it would not be vegetarian. The route is not usually declared.

  • Vegan status depends on the source
  • Vegetarian status depends on the source
  • May raise a halal question
  • May raise a kosher question

This is not an omission. What this additive is made from is not fixed — depending on the manufacturer it may be plant, animal or microbial in origin, nobody is required to say which, and the same product can change source between production runs. Ask the manufacturer if it matters to you; a label cannot answer it.

CAS registry number
4691-65-0
InChIKey
AANLCWYVVNBGEE-IDIVVRGQSA-L
PubChem
CID 135414245

Every name it appears under

50 recorded names. A label may use any of them.

E number

  • E631

INS number

  • 631

CAS registry number

  • 4691-65-0

As it appears in regulation

  • Disodium inosinate

Other names

  • 5'-IMP 2Na
  • 5'-Imp disodium salt
  • 5'-IMPdisodium salt
  • 5'-INOSINIC ACID, DISODIUM SALT
  • 5'-Inosinic acid, sodium salt (1:2)
  • 5?Inosinic Acid Disodium Salt
  • CCRIS 6560
  • Disodium 5'-inosinate
  • disodium 5'-O-phosphonatoinosine
  • disodium 5’-inosinate
  • Disodium inosinate
  • Disodium inosine 5'-monophosphate
  • Disodium inosine 5'-phosphate
  • Disodium inosine-5'-monophosphate
  • E 631
  • E 631 (FOOD ENHANCEMENT AGENT)
  • FEMA No. 3669
  • IMP
  • IMP disodium salt
  • IMP sodium salt
  • IMP.Na2
  • Inosic Acid Disodium Salt
  • Inosin-5'-monophosphate disodium
  • inosin-5’-monophosphatedisodium
  • Inosinate, Sodium
  • Inosine 5'-monophosphate disodium
  • Inosine 5'-monophosphate disodium salt
  • inosine 5'-monophosphoric acid disodium salt
  • Inosine monophosphate disodium
  • Inosine-5 inverted exclamation mark -monophosphate Disodium Salt
  • Inosine-5'-monophosphate disodium
  • Inosine-5'-monophosphateDisodiumSalt
  • Inosine-5'-monophosphoric acid disodium salt
  • INS NO.631
  • INS-631
  • Ribotide
  • Sodium 5'-inosinate
  • Sodium inosinate
  • Sodium Inosine 5'-Phosphate (2:1)
  • Sodium isosin-monophosphate
  • T2ZYA7KC05

Systematic names

  • [(3S,2R,4R,5R)-3,4-dihydroxy-5-(6-oxohydropurin-9-yl)oxolan-2-yl]methyl dihydr ogen phosphate, sodium salt, sodium salt
  • disodium [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-hydroxy-9H-purin-9-yl)oxolan-2-yl]methyl phosphate
  • disodium [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl phosphate
  • disodium;[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl phosphate
  • sodium ((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-hydroxy-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl phosphate

Hazard reference values

No reference value for this substance in the sources we hold.

Evidence and how bodies read it

Studies, and the differing conclusions regulators drew from them, are curated by hand rather than machine-read, and none has been written for this substance yet.

Sources for this page

  • ecfr retrieved 2026-09-07
  • gsfa retrieved 2026-09-07

Full licence terms and publisher details on Sources. How this page is built and updated: Method.

Machine-readable:/api/v1/additives/disodium-inosinate.json