Glucose isomerase from Streptomyces rubiginosus
9055-00-9 · (2-chlorophenyl)[4-(phenylsulfonyl)piperazin-1-yl]methanone · (2-CHLOROPHENYL)[4-(PHENYLSULFONYL)PIPERAZINO]METHANONE · 1-(benzenesulfonyl)-4-[(2-chlorophenyl)carbonyl]piperazine · 2-chlorophenyl 4-(phenylsulfonyl)piperazinyl ketone · [4-(benzenesulfonyl)piperazin-1-yl]-(2-chlorophenyl)methanone · [4-(benzenesulonyl)piperazin-1-yl]-(2-chlorophenyl)methanone · GLUCOSE ISOMERASE FROM STREPTOMYCES · Glucose isomerase from Streptomyces rubiginosus · Glucose isomerases · Isomerase, glucose · WNQJZQMIEZWFIN-UHFFFAOYSA-N · Xylose isomeraseListed as an enzyme by the US.
Listed as enzymes (US)
- United States: Enzyme — FDA, Substances Added to Food: GLUCOSE ISOMERASE FROM STREPTOMYCES RUBIGINOSUS
- United States: Enzymes — 21 CFR 184.1372, citing 21 CFR 170.3(o)(9)
A glucose isomerase from Streptomyces rubiginosus, used in making fructose syrups from starch-derived glucose. It is among the most widely used of the immobilised industrial enzymes.
Where it is and isn’t permitted
| Jurisdiction | Status | Scope and limits | Citation |
|---|---|---|---|
| Australia and New Zealand | No listed food uses foundThis site has not matched this substance to any food use on this jurisdiction’s list of authorised food additives. A food additive may be used only in foods that list names. Flavourings, enzymes, processing aids and added nutrients are regulated separately and do not appear on it. | ||
| Canada | No listing matchedHealth Canada’s lists name additives without E or INS numbers, so this site matches them by exact name. A substance listed there under a name this site does not recognise has no row here. | ||
| European Union | No listed food uses foundThis site has not matched this substance to any food use on this jurisdiction’s list of authorised food additives. A food additive may be used only in foods that list names. Flavourings, enzymes, processing aids and added nutrients are regulated separately and do not appear on it. | ||
| Great Britain | No listed food uses foundThis site has not matched this substance to any food use on this jurisdiction’s list of authorised food additives. A food additive may be used only in foods that list names. Flavourings, enzymes, processing aids and added nutrients are regulated separately and do not appear on it. | ||
| Japan | No listing matchedThis site imports only Japan’s list of designated additives (Appended Table 1 to the Regulations for Enforcement of the Food Sanitation Act), matched by English name. Existing additives, natural flavouring agents and ordinary foods used as additives are permitted outside that list and are not imported, so an empty row does not show that Japan does not permit the substance. | ||
| South Korea | No listing matchedThis site imports Part III of South Korea’s Standards and Specifications for Food Additives, matched by CAS number, then INS number, then exact name. Mixed preparations and sanitisers are not imported, and an entry whose identifiers disagreed with a page’s is held for review, so an empty row does not show that South Korea does not permit the substance. | ||
| United States | Permitted | Named in 21 CFR 184.1372, which affirms as generally recognized as safe the insoluble glucose isomerase enzyme preparations used in producing high fructose corn syrup, derived from …Named in 21 CFR 184.1372, which affirms as generally recognized as safe the insoluble glucose isomerase enzyme preparations used in producing high fructose corn syrup, derived from microorganisms including Streptomyces rubiginosus. The section is held on this site as the page insoluble-glucose-isomerase-enzyme-preparations; read it for the conditions. | 21 CFR 184.1372retrieved 2026-10-18 |
| Codex Alimentarius | Not listedDoes not appear on this jurisdiction’s permitted list. That is not the same as being prohibited. |
How much is permitted
A listing usually limits the quantity as well as the food. Only one of the forms that takes is a figure: quantum satis and good manufacturing practice permit the amount the technological effect requires and no more, which is a limit rather than the absence of one. Figures below are the range across every food category this page is listed in, and categories differ between regulators — see how much is permitted.
| United States | — | 1 no quantity stated |
|---|
No regulator sets a figure for Glucose isomerase from Streptomyces rubiginosus. That is not an absence of control: where the listing says quantum satis or good manufacturing practice, the quantity is limited to what the effect requires.
What it is made from
Produced by fermenting Streptomyces rubiginosus, usually supplied immobilised on a carrier.
- InChIKey
- WNQJZQMIEZWFIN-UHFFFAOYSA-N
- PubChem
- CID 1151718
How JECFA defines it
The international specification for identity and purity, prepared by the Joint FAO/WHO Expert Committee on Food Additives and published by FAO. It is a different document from any above, written by a different body and revised on its own cycle; it is advisory, and a country adopts it or does not.
Glucose Isomerase from Streptomyces rubiginosus
Synonyms: Xylose isomerase
Assay, identification and purity criteria
Description and assay
- Specification history
- Prepared at the 29th JECFA (1985), published in FNP 34 (1986) and in FNP 52 (1992). No ADI was allocated at the 29th JECFA (1985)
- SYNONYMS SOURCES Active principles Systematic names and numbers Reactions catalyzed
- Xylose isomerase Produced by the controlled fermentation of Streptomyces rubiginosus Xylose isomerase (glucose isomerase) D-Xylose ketol-isomerase (EC 5.3.1.5) D-Xylose and D-glucose are converted to D-xylulose and D-fructose, respectively
- DESCRIPTION
- Off-white to brown granules (immobilized preparation) or liquids, insoluble in water (granules), ethanol, chloroform and ether The immobilized preparations are rendered insoluble in water by disruption of the organism, absorption of the cell-free extract onto diethylaminoethyl cellulose (DEAE cellulose)
- FUNCTIONAL USES
- Enzyme preparation Used in the preparation of high fructose corn syrup and other fructose starch syrups.
- GENERAL SPECIFICATIONS Glucose isomerase activity (Vol. 4)
- Must conform to the General Specifications for Enzyme Preparations used in Food Processing (see Volume Introduction) The sample shows glucose isomerase activity
Every name it appears under
13 recorded names. A label may use any of them.
CAS registry number
- 9055-00-9
Other names
- (2-chlorophenyl)[4-(phenylsulfonyl)piperazin-1-yl]methanone
- (2-CHLOROPHENYL)[4-(PHENYLSULFONYL)PIPERAZINO]METHANONE
- 1-(benzenesulfonyl)-4-[(2-chlorophenyl)carbonyl]piperazine
- 2-chlorophenyl 4-(phenylsulfonyl)piperazinyl ketone
- [4-(benzenesulfonyl)piperazin-1-yl]-(2-chlorophenyl)methanone
- [4-(benzenesulonyl)piperazin-1-yl]-(2-chlorophenyl)methanone
- GLUCOSE ISOMERASE FROM STREPTOMYCES
- Glucose isomerase from Streptomyces rubiginosus
- Glucose isomerases
- Isomerase, glucose
- WNQJZQMIEZWFIN-UHFFFAOYSA-N
- Xylose isomerase
Hazard reference values
No reference value for this substance in the sources we hold.
Evidence and how bodies read it
Studies, and the differing conclusions regulators drew from them, are curated rather than machine-read, and none has been written for this substance yet.
Common questions
Assembled from what is above, in the words the questions are usually asked in. Each answer is the same statement the relevant section makes, with the same citations behind it.
- What is Glucose isomerase from Streptomyces rubiginosus?
- A glucose isomerase from Streptomyces rubiginosus, used in making fructose syrups from starch-derived glucose. It is among the most widely used of the immobilised industrial enzymes.
- What is Glucose isomerase from Streptomyces rubiginosus used for in food?
- It is listed as an enzyme — the role the US assigns it. This page shows every function each regulator records, with the citation for each.
- Is Glucose isomerase from Streptomyces rubiginosus banned in Europe?
- No. Glucose isomerase from Streptomyces rubiginosus is not on the EU's list of authorised food additives, but it would not be expected to be: every role regulators give it — enzyme — the EU regulates under separate law. Its absence from the additives list says nothing about whether it is permitted in Europe.
- Where is Glucose isomerase from Streptomyces rubiginosus permitted?
- Of the seven regulators this site reads, the US permits it. Each permission is for named foods at named levels, not a blanket one; the table on this page gives them with citations.
Sources for this page
- us-listings retrieved 2026-10-18
- jecfaspecs retrieved 2026-09-23
Full licence terms and publisher details on Sources. How this page is built and updated: Method.
Machine-readable: a JSON record of this additive is given on request —how to ask for access.
Follow changes to Glucose isomerase from Streptomyces rubiginosus:Atom feed — regulatory events, and any change the weekly refresh detects in its provisions.