Calcium gluconate

INS 578CAS 299-28-5

Used as an acidity regulator — Codex also lists it as firming agent, sequestrant.

Calcium gluconate is a firming agent and calcium fortificant, used in canned fruit and vegetables and in supplements.

Where it is and isn’t permitted

Status of Calcium gluconate by jurisdiction. Every jurisdiction this site covers is listed, including those where the substance does not appear.
JurisdictionStatusScope and limitsCitation
United StatesFood and Drug AdministrationPermitted21 CFR 184.1199retrieved 2026-09-07
Codex AlimentariusCodex Alimentarius Commission / JECFAPermitted, with conditions

1 food category

no numerical limit (good manufacturing practice)

CXS 192-1995 Table Three, INS 578and 1 further provisionretrieved 2026-09-07

What it is made from

Made by fermenting glucose to gluconic acid and neutralising it with a calcium base.

  • Vegan
  • Vegetarian
CAS registry number
299-28-5
InChIKey
NEEHYRZPVYRGPP-IYEMJOQQSA-L
PubChem
CID 9290

Every name it appears under

50 recorded names. A label may use any of them.

INS number

  • 578

CAS registry number

  • 299-28-5

As it appears in regulation

  • Calcium gluconate

Other names

  • 2,3,4,5,6-Pentahydroxycaproic Acid hemicalcium salt
  • 23% Calcium Gluconate
  • C12H22CaO14
  • Calcarea gluconica
  • Calcicol
  • Calcii gluconas
  • Calciofon
  • Calcipur
  • calcium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
  • Calcium D-gluconate
  • Calcium D-gluconate (1:2)
  • Calcium D-gluconate;Gluconic acid hemicalcium salt
  • calcium di(D-gluconate)
  • Calcium di-gluconate
  • CALCIUM GLUCONATE
  • Calcium gluconate (USP)
  • Calcium Gluconate 1.5%
  • Calcium Gluconate 23% Solution
  • Calcium gluconate anhydrous
  • Calcium gluconate hydrate
  • CALCIUM GLUCONATE IN SODIUM CHLORIDE
  • Calcium hexagluconate
  • Calglucol
  • Calglucon
  • CCRIS 1336
  • D-Gluconic acid calcium salt
  • D-GLUCONIC ACID HEMICALCIUM SALT
  • D-Gluconic acid, calcium salt (2:1)
  • Dragocal
  • Ebucin
  • Glucal
  • Glucobiogen
  • Gluconate de calcium
  • Gluconate, Calcium
  • Gluconato di calcio
  • Gluconic Acid Calcium Salt
  • Gluconic acid hemicalcium salt
  • Gluconic acid, calcium salt (2:1), D-
  • GZE CUTICLE REMOVER
  • H-f antidote
  • HSDB 994
  • INS NO.578
  • INS-578
  • Kalpren
  • Novocal
  • SQE6VB453K
  • Sykes Calcium Gluconate 23%

Hazard reference values

No reference value for this substance in the sources we hold.

Evidence and how bodies read it

Studies, and the differing conclusions regulators drew from them, are curated by hand rather than machine-read, and none has been written for this substance yet.

Sources for this page

  • ecfr retrieved 2026-09-07
  • gsfa retrieved 2026-09-07

Full licence terms and publisher details on Sources. How this page is built and updated: Method.

Machine-readable:/api/v1/additives/calcium-gluconate.json